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Tbio
AK4
Adenylate kinase 4, mitochondrial

Protein Summary
Description
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and N ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327299
  • ENSP00000322175
  • ENSG00000162433
  • ENST00000395334
  • ENSP00000378743
  • ENST00000545314
  • ENSP00000445912

Symbol
  • AK3
  • AK3L1
  • AK3
  • AK 4
  • AK3L1
  • AK3L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.95
gene perturbation
0.95
small molecule perturbation
0.95
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.63   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.63   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
2
2
98.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
98.1
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (123)
1 – 10 of 123
RABIF
Tbio
Novelty: 0.22512579
p_int: 0.994681482
p_ni: 0.005318512
p_wrong: 6e-9
Data Source: BioPlex
TFAP2B
Tbio
Family: TF
Novelty: 0.01383202
p_int: 0.991602769
p_ni: 0.006019137
p_wrong: 0.002378094
Data Source: BioPlex
GTF2E2
Tbio
Novelty: 0.18033153
p_int: 0.981286088
p_ni: 0.01871377
p_wrong: 1.43e-7
Data Source: BioPlex
ATF6B
Tbio
Family: TF
Novelty: 0.07061573
p_int: 0.97925853
p_ni: 0.020741469
p_wrong: 1e-9
Score: 0.204
Data Source: BioPlex,STRINGDB
NSDHL
Tbio
Family: Enzyme
Novelty: 0.01651408
p_int: 0.95950034
p_ni: 0.040498004
p_wrong: 0.000001656
Data Source: BioPlex
CXCL14
Tbio
Novelty: 0.00606628
p_int: 0.958984514
p_ni: 0.036980366
p_wrong: 0.00403512
Data Source: BioPlex
OXLD1
Tdark
Family: Enzyme
Novelty: 23
p_int: 0.958741923
p_ni: 0.041256557
p_wrong: 0.00000152
Score: 0.183
Data Source: BioPlex,STRINGDB
CCL5
Tchem
Novelty: 0.00032607
p_int: 0.951429026
p_ni: 0.048570782
p_wrong: 1.92e-7
Score: 0.209
Data Source: BioPlex,STRINGDB
ZMYM6
Tdark
Novelty: 0.4933879
p_int: 0.895987479
p_ni: 0.104003954
p_wrong: 0.000008566
Data Source: BioPlex
TNRC6A
Tbio
Novelty: 0.00505282
p_int: 0.895987479
p_ni: 0.104003954
p_wrong: 0.000008566
Data Source: BioPlex
Publication Statistics
PubMed Score  100.63

PubMed score by year
PubTator Score  17.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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