Tbio AK4 Adenylate kinase 4, mitochondrial

Protein Summary

Description

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P27144
• B2R927
• D3DQ62
• Q6IBH4
• Q6NXQ5
• Q8IUU9
• AK 4

Gene Name

• AK4

Ensembl ID

• ENST00000327299
• ENSP00000322175
• ENSG00000162433
• ENST00000395334
• ENSP00000378743
• ENST00000545314
• ENSP00000445912

Symbol

• AK3
• AK3L1
• AK3
• AK 4
• AK3L1
• AK3L2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
disease perturbation	0.95
gene perturbation	0.95
small molecule perturbation	0.95
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Nucleotide Kinase / Adenylate Kinase 4, Mitochondrial

DTO Classes

Protein / Kinase / Unclassified Protein / Adenylate Kinase 4, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.89   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 377   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.89   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0