Tchem ACVR2A Activin receptor type-2A

Protein Summary

Description

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity). This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• P27037
• B2RAB8
• B4DWQ2
• D3DP85
• Q53TH4
• Q6NWV2
• Q92474

Gene Name

• ACVR2A

Ensembl ID

• ENST00000241416
• ENSP00000241416
• ENSG00000121989
• ENST00000404590
• ENSP00000384338
• ENST00000535787
• ENSP00000439988

Symbol

• ACVR2
• ACVR2
• ACTRII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
disease perturbation	0.93
biological process	0.92
histone modification site profile	0.78
transcription factor binding site profile	0.77

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Serine/threonine Protein Kinase Receptor / Activin Receptor Type-2a

Protein / Receptor / Protein Kinase Receptor / Serine/threonine Protein Kinase Receptor / Activin Receptor Type-2a

Protein / Receptor / Cytokine Receptor / Tgf-beta Receptor / Activin Receptor Type-2a

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Stkr Family / Stkr Type 2 Subfamily / Activin Receptor Type-2a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.03   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 441   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.03   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0