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Tchem
MST1
Hepatocyte growth factor-like protein

Protein Summary
Description
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383728
  • ENSP00000373234
  • ENSG00000173531

Symbol
  • D3F15S2
  • DNF15S2
  • HGFL
  • MSP
  • HGFL
  • NF15S2
  • D3F15S2
  • DNF15S2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
gene perturbation
0.74
virus perturbation
0.72
histone modification site profile
0.66
phenotype
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.23   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.23   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1)
1 – 1 of 1
SID103904636
Rendered image for SID103904636
Protein-Protein Interactions (53)
1 – 10 of 53
MST1R
Tchem
Family:  Kinase
Novelty:  0.002318
Score:  0.998
Data Source:  Reactome,STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.958
Data Source:  STRINGDB
SPINT1
Tbio
Family:  Enzyme
Novelty:  0.00930324
Score:  0.936
Data Source:  STRINGDB
FOXO3
Tbio
Family:  TF
Novelty:  0.00074316
Score:  0.925
Data Source:  STRINGDB
HPN
Tchem
Family:  Enzyme
Novelty:  0.00713738
Score:  0.916
Data Source:  Reactome,STRINGDB
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
Score:  0.915
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.908
Data Source:  STRINGDB
ICAM1
Tchem
Novelty:  0.00009746
Score:  0.905
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.903
Data Source:  STRINGDB
YWHAE
Tbio
Novelty:  0.00431876
Score:  0.901
Data Source:  STRINGDB
Pathways (21)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by MST1
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by MST1
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
6
5
8.2
98.9
mathematical ability
4
5
6
98.5
reticulocyte count
2
3
3
96.4
intelligence
4
6
3
8.2
95.6
household income
2
5
6
93.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
8.2
98.9
mathematical ability
6
98.5
reticulocyte count
3
96.4
intelligence
3
8.2
95.6
household income
6
93.3
Find similar targets by:
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96080
15235
Rat
RGD:3114
24566
Dog
macrophage stimulating 1
484768
Cow
macrophage stimulating 1
514667
Pig
macrophage stimulating 1
100512987
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
macrophage stimulating 1
Cow
macrophage stimulating 1
Pig
macrophage stimulating 1
Publication Statistics
PubMed Score 110.23
PubMed score by year
PubTator Score 283.87
PubTator score by year