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Tchem
FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2

Protein Summary
Description
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309366
  • ENSP00000310935
  • ENSG00000173486
  • ENST00000394540
  • ENSP00000378046
  • ENST00000449942
  • ENSP00000398147

Symbol
  • FKBP13
  • PPIase
  • FKBP-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor
0.84
transcription factor binding site profile
0.75
virus perturbation
0.72
cell type or tissue
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.37   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.37   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (112)
PPIB
Tchem
Family:  Enzyme
Novelty:  0.00309224
Score:  0.951
Data Source:  STRINGDB
TAGLN
Tbio
Novelty:  0.00243855
Score:  0.88
Data Source:  STRINGDB
FKBP1A
Tclin
Family:  Enzyme
Novelty:  0.00116174
Score:  0.844
Data Source:  STRINGDB
PIN1
Tchem
Family:  Enzyme
Novelty:  0.00957198
Score:  0.818
Data Source:  STRINGDB
MAP3K11
Tchem
Family:  Kinase
Novelty:  0.01112378
Score:  0.794
Data Source:  STRINGDB
COX8A
Tbio
Family:  Enzyme
Novelty:  0.00796737
Score:  0.788
Data Source:  STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.769
Data Source:  STRINGDB
FOSL1
Tbio
Family:  TF
Novelty:  0.00294254
Score:  0.769
Data Source:  STRINGDB
P62861
Tbio
Novelty:  0.01170009
Score:  0.769
Data Source:  STRINGDB
SF1
Tbio
Novelty:  0.01538883
Score:  0.765
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (47)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
7
8
97.3
BMI-adjusted waist-hip ratio
6
7
11
97.3
urate measurement
1
5
5
94.4
triglyceride measurement
4
3
4
93.5
high density lipoprotein cholesterol measurement
5
3
5
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
8
97.3
BMI-adjusted waist-hip ratio
11
97.3
urate measurement
5
94.4
triglyceride measurement
4
93.5
high density lipoprotein cholesterol measurement
5
92.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein 2
VGNC:11771
743135
Mouse
MGI:95542
14227
Rat
RGD:1560660
293702
Dog
FK506 binding protein 2
VGNC:40889
483764
Horse
FK506 binding protein 2
VGNC:18050
100055318
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FK506 binding protein 2
Mouse
Rat
Dog
FK506 binding protein 2
Horse
FK506 binding protein 2
Publication Statistics
PubMed Score 104.37
PubMed score by year
PubTator Score 25.78
PubTator score by year
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Related Publications
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PMID
Year
Title