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Tbio
CD27
CD27 antigen

Protein Summary
Description
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266557
  • ENSP00000266557
  • ENSG00000139193

Symbol
  • TNFRSF7
  • T14
  • S152
  • Tp55
  • TNFRSF7
  • S152. LPFS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
biological term
0.75
cell type or tissue
0.7
gene perturbation
0.7
tissue sample
0.64


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1099.87   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 1851   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1099.87   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 1851   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD27 molecule
VGNC:5329
451780
Macaque
CD27 molecule
712693
Mouse
MGI:88326
21940
Rat
RGD:1560499
500318
Dog
CD27 molecule
VGNC:38941
611674
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD27 molecule
Macaque
CD27 molecule
Mouse
Rat
Dog
CD27 molecule
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P26842-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNFR2 non-canonical NF-kB pathway
Reactome
TNFs bind their physiological receptors
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
Protein-Protein Interactions (243)
1 – 10 of 243
SLC25A51
Tdark
Family: Transporter
Novelty: 0.21568087
p_int: 0.999988721
p_ni: 0.000011277
p_wrong: 2e-9
Score: 0.205
Data Source: BioPlex,STRINGDB
C1GALT1
Tbio
Family: Enzyme
Novelty: 0.01191596
p_int: 0.999988104
p_ni: 0.000011896
Score: 0.222
Data Source: BioPlex,STRINGDB
CD70
Tbio
Novelty: 0.00420393
p_int: 0.999982532
p_ni: 0.00001164
p_wrong: 0.000005827
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
TCAF2
Tbio
Family: Enzyme
Novelty: 0.37070492
p_int: 0.999946877
p_ni: 0.00005307
p_wrong: 5.4e-8
Data Source: BioPlex
TMEM67
Tbio
Novelty: 0.02573267
p_int: 0.999944553
p_ni: 0.000055447
Data Source: BioPlex
SEMG2
Tbio
Novelty: 0.06325799
p_int: 0.99717293
p_ni: 0.00282707
Data Source: BioPlex
SEMG1
Tbio
Novelty: 0.0161449
p_int: 0.996792559
p_ni: 0.003207402
p_wrong: 3.9e-8
Data Source: BioPlex
ATP2B3
Tbio
Family: Transporter
Novelty: 0.00901493
p_int: 0.99311844
p_ni: 0.006881548
p_wrong: 1.2e-8
Data Source: BioPlex
GOLGA5
Tbio
Novelty: 0.04940885
p_int: 0.991098275
p_ni: 0.008901725
Data Source: BioPlex
SLC19A2
Tbio
Family: Transporter
Novelty: 0.00761796
p_int: 0.990357235
p_ni: 0.009642765
Data Source: BioPlex
Publication Statistics
PubMed Score  1099.87

PubMed score by year
PubTator Score  695.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer