Tbio KLRC1 NKG2-A/NKG2-B type II integral membrane protein

Protein Summary

Description

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P26715

Gene Name

• KLRC1

Ensembl ID

• ENST00000347831
• ENSP00000256965
• ENSG00000134545
• ENST00000359151
• ENSP00000352064
• ENST00000408006
• ENSP00000385304
• ENST00000544822
• ENSP00000438038

Symbol

• NKG2A
• NKG2
• NKG2A
• CD159A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.71
cell line	0.61
PubMedID	0.6
molecular function	0.53
biological term	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 381.62   (req: < 5)

Gene RIFs: 81   (req: <= 3)

Antibodies: 561   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 381.62   (req: >= 5)

Gene RIFs: 81   (req: > 3)

Antibodies: 561   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0