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Tbio
KLRC1
NKG2-A/NKG2-B type II integral membrane protein

Protein Summary
Description
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been obse ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347831
  • ENSP00000256965
  • ENSG00000134545
  • ENST00000359151
  • ENSP00000352064
  • ENST00000408006
  • ENSP00000385304
  • ENST00000544822
  • ENSP00000438038

Symbol
  • NKG2A
  • NKG2
  • NKG2A
  • CD159A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.71
cell line
0.61
PubMedID
0.6
molecular function
0.53
biological term
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.07   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 561   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.07   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 561   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
83.6
mean corpuscular volume
1
1
1
49.7
granulocyte percentage of myeloid white cells
1
1
1
46.7
monocyte percentage of leukocytes
1
1
1
43
mean reticulocyte volume
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
83.6
mean corpuscular volume
1
49.7
granulocyte percentage of myeloid white cells
1
46.7
monocyte percentage of leukocytes
1
43
mean reticulocyte volume
1
39.6
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
killer cell lectin like receptor C1
VGNC:8432
450131
Mouse
MGI:1336161
16641
Horse
NKG2-A/NKG2-B type II integral membrane protein-like
100062846
Cow
NKG2-A/NKG2-B type II integral membrane protein-like
514897
Pig
NKG2-A/NKG2-B type II integral membrane protein
100523789
Species
Name
OMA
EggNOG
Inparanoid
Chimp
killer cell lectin like receptor C1
Mouse
Horse
NKG2-A/NKG2-B type II integral membrane protein-like
Cow
NKG2-A/NKG2-B type II integral membrane protein-like
Pig
NKG2-A/NKG2-B type II integral membrane protein
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P26715-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Protein-Protein Interactions (165)
1 – 10 of 165
HLA-E
Tbio
Novelty: 0.00216583
Score: 0.999
Data Source: Reactome,STRINGDB
B2M
Tbio
Novelty: 0.00011248
Score: 0.992
Data Source: Reactome,STRINGDB
PTPN6
Tchem
Family: Enzyme
Novelty: 0.00535749
Score: 0.991
Data Source: STRINGDB
KLRD1
Tbio
Novelty: 0.00218019
Score: 0.989
Data Source: Reactome,STRINGDB
KIR2DL1
Tbio
Novelty: 0.00523657
Score: 0.972
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.968
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.968
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.968
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.968
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  321.07

PubMed score by year
PubTator Score  406.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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