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Tbio
PLN
Cardiac phospholamban

Protein Summary
Description
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. T ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357525
  • ENSP00000350132
  • ENSG00000198523

Symbol
  • PLB
  • PLB
  • CMD1P
  • CMH18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
biological term
0.83
cell type or tissue
0.78
PubMedID
0.7
cellular component
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.26   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 463   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.26   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 463   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
ATP2A2
Tchem
Family:  Transporter
Novelty:  0.00133604
Score:  0.976
Data Source:  STRINGDB
ATP2A1
Tchem
Family:  Transporter
Novelty:  0.00355092
Score:  0.965
Data Source:  STRINGDB
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
Score:  0.959
Data Source:  STRINGDB
DMPK
Tchem
Family:  Kinase
Novelty:  0.00242339
Score:  0.946
Data Source:  Reactome,STRINGDB
SLN
Tbio
Novelty:  0.00504194
Score:  0.942
Data Source:  STRINGDB
PRKACA
Tchem
Family:  Kinase
Novelty:  0.03869658
Score:  0.935
Data Source:  Reactome,STRINGDB
ATP2B4
Tbio
Family:  Transporter
Novelty:  0.00560356
Score:  0.919
Data Source:  STRINGDB
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
Score:  0.905
Data Source:  STRINGDB
PRKG2
Tchem
Family:  Kinase
Novelty:  0.0138455
Score:  0.9
Data Source:  STRINGDB
NOS1
Tchem
Family:  Enzyme
Novelty:  0.00032064
Score:  0.9
Data Source:  STRINGDB
Pathways (13)
Cardiac conduction (R-HSA-5576891)

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Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
66.8
QRS duration
1
1
1
65.6
QT interval
1
1
0
1.8
59.5
left ventricular structural measurement
4
1
4
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
66.8
QRS duration
1
65.6
QT interval
0
1.8
59.5
left ventricular structural measurement
4
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97622
18821
Rat
RGD:619894
64672
Dog
phospholamban
VGNC:44700
414755
Horse
phospholamban
VGNC:21584
100630668
Cow
phospholamban
VGNC:33038
100125240
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phospholamban
Horse
phospholamban
Cow
phospholamban
Publication Statistics
PubMed Score 62.26
PubMed score by year
PubTator Score 320.40
PubTator score by year
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Related Publications
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PMID
Year
Title