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Tbio
EEF1G
Elongation factor 1-gamma

Protein Summary
Description
Probably plays a role in anchoring the complex to other cellular components. This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329251
  • ENSP00000331901
  • ENSG00000254772

Symbol
  • EF1G
  • EF1G
  • GIG35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
small molecule perturbation
1
disease perturbation
0.96
kinase perturbation
0.95
hub protein
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.88   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 333   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.88   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
2
3
21.4
physical activity measurement
1
1
2
9.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
21.4
physical activity measurement
2
9.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation elongation factor 1 gamma
VGNC:11344
451253
Macaque
eukaryotic translation elongation factor 1 gamma
722274
Mouse
MGI:1914410
67160
Rat
RGD:1302939
293725
Dog
eukaryotic translation elongation factor 1 gamma
611396
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation elongation factor 1 gamma
Macaque
eukaryotic translation elongation factor 1 gamma
Mouse
Rat
Dog
eukaryotic translation elongation factor 1 gamma
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P26641-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Eukaryotic Translation Elongation (R-HSA-156842)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Eukaryotic Translation Elongation
Reactome
Metabolism of proteins
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Eukaryotic Translation Elongation
Metabolism of proteins
Translation
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (427)
1 – 10 of 427
EEF1A2
Tchem
Novelty: 0.001472
p_int: 0.999999201
p_ni: 7.99e-7
Score: 0.979
Data Source: BioPlex,STRINGDB
MKKS
Tbio
Novelty: 0.00805347
p_int: 0.999998311
p_ni: 1.73e-7
p_wrong: 0.000001516
Score: 0.911
Data Source: BioPlex,STRINGDB
CARS
Tbio
Family: Enzyme
Novelty: 0.02078279
p_int: 0.99998633
p_ni: 0.00001367
Score: 0.997
Data Source: BioPlex,STRINGDB
EEF1D
Tbio
Novelty: 0.02480745
p_int: 0.999894076
p_ni: 0.000105924
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
VARS
Tchem
Family: Enzyme
Novelty: 0.00720227
p_int: 0.999629132
p_ni: 0.000370867
Score: 0.9
Data Source: BioPlex,STRINGDB
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00634126
p_int: 0.997525174
p_ni: 0.002474826
Score: 0.176
Data Source: BioPlex,STRINGDB
EEF1A1
Tchem
Novelty: 0.00059953
p_int: 0.995997141
p_ni: 0.004002859
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EEF1B2
Tbio
Novelty: 0.00970356
p_int: 0.992188584
p_ni: 0.007811416
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KTN1
Tbio
Novelty: 0.01436672
p_int: 0.926602289
p_ni: 0.07339771
p_wrong: 1e-9
Score: 0.737
Data Source: BioPlex,STRINGDB
RPS2
Tbio
Novelty: 0.00412313
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.88

PubMed score by year
PubTator Score  28.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer