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Tbio
PTBP1
Polypyrimidine tract-binding protein 1

Protein Summary
Description
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806). This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA proce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349038
  • ENSP00000014112
  • ENSG00000011304
  • ENST00000356948
  • ENSP00000349428
  • ENST00000394601
  • ENSP00000408096

Symbol
  • PTB
  • PTB
  • PTB2
  • PTB3
  • PTB4
  • pPTB
  • HNRPI
  • PTB-1
  • PTB-T
  • HNRNPI
  • HNRNP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor binding site profile
0.96
kinase perturbation
0.95
hub protein
0.88
ligand (protein) perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 527.36   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 404   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 527.36   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 404   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
3
88.9
hemoglobin measurement
2
2
3
88.3
C-reactive protein measurement
1
1
1
66.7
heel bone mineral density
1
1
1
65.1
cup-to-disc ratio measurement
1
1
1
45.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
88.9
hemoglobin measurement
3
88.3
C-reactive protein measurement
1
66.7
heel bone mineral density
1
65.1
cup-to-disc ratio measurement
1
45.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polypyrimidine tract binding protein 1
VGNC:2267
749887
Macaque
polypyrimidine tract binding protein 1
703430
Mouse
MGI:97791
19205
Rat
RGD:62047
29497
Dog
polypyrimidine tract binding protein 1
485097
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polypyrimidine tract binding protein 1
Macaque
polypyrimidine tract binding protein 1
Mouse
Rat
Dog
polypyrimidine tract binding protein 1
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
FGFR2 alternative splicing (R-HSA-6803529)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR2 alternative splicing
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Name
Explore in Pharos
Explore in Source
FGFR2 alternative splicing
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Signal Transduction
Signaling by FGFR
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (424)
1 – 10 of 424
HNRNPK
Tbio
Novelty: 0.00354731
Score: 0.999
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.999
Data Source: Reactome,STRINGDB
HNRNPL
Tbio
Novelty: 0.01048413
Score: 0.999
Data Source: STRINGDB
HNRNPA2B1
Tbio
Novelty: 0.00404935
Score: 0.999
Data Source: STRINGDB
ELAVL1
Tchem
Novelty: 0.00110045
Score: 0.999
Data Source: STRINGDB
SRSF3
Tbio
Novelty: 0.01015895
Score: 0.998
Data Source: STRINGDB
HNRNPA0
Tbio
Novelty: 0.10233768
Score: 0.998
Data Source: STRINGDB
HNRNPC
Tbio
Novelty: 0.00136097
Score: 0.998
Data Source: STRINGDB
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.998
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  527.36

PubMed score by year
PubTator Score  710.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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