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Tbio
PTBP1
Polypyrimidine tract-binding protein 1

Protein Summary
Description
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806). This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA proce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349038
  • ENSP00000014112
  • ENSG00000011304
  • ENST00000356948
  • ENSP00000349428
  • ENST00000394601
  • ENSP00000408096

Symbol
  • PTB
  • PTB
  • PTB2
  • PTB3
  • PTB4
  • pPTB
  • HNRPI
  • PTB-1
  • PTB-T
  • HNRNPI
  • HNRNP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor binding site profile
0.96
kinase perturbation
0.95
hub protein
0.88
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.66   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 404   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.66   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 404   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
FGFR2 alternative splicing (R-HSA-6803529)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR2 alternative splicing
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Name
Explore in Pharos
Explore in Source
FGFR2 alternative splicing
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Signal Transduction
Signaling by FGFR
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (424)
1 – 10 of 424
HNRNPK
Tbio
Novelty: 0.00343899
Score: 0.999
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.00262355
Score: 0.999
Data Source: Reactome,STRINGDB
HNRNPL
Tbio
Novelty: 0.00274698
Score: 0.999
Data Source: STRINGDB
HNRNPA2B1
Tbio
Novelty: 0.00503583
Score: 0.999
Data Source: STRINGDB
ELAVL1
Tchem
Novelty: 0.00158015
Score: 0.999
Data Source: STRINGDB
SRSF3
Tbio
Novelty: 0.0126411
Score: 0.998
Data Source: STRINGDB
HNRNPA0
Tbio
Novelty: 0.14247679
Score: 0.998
Data Source: STRINGDB
HNRNPC
Tbio
Novelty: 0.00195495
Score: 0.998
Data Source: STRINGDB
SRSF1
Tbio
Novelty: 0.00119334
Score: 0.998
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01807307
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  450.66

PubMed score by year
PubTator Score  710.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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