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Tbio
HMGB2
High mobility group protein B2

Protein Summary
Description
Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic aci ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296503
  • ENSP00000296503
  • ENSG00000164104
  • ENST00000438704
  • ENSP00000404912
  • ENST00000446922
  • ENSP00000393448

Symbol
  • HMG2
  • HMG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
interacting protein
0.99
virus perturbation
0.97
hub protein
0.95
transcription factor perturbation
0.91


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.6   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 363   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.6   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 363   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
high mobility group box 2
VGNC:613
461606
Macaque
high mobility group box 2
697057
Mouse
MGI:96157
97165
Rat
29395
Dog
high mobility group box 2
VGNC:41710
486068
Species
Name
OMA
EggNOG
Inparanoid
Chimp
high mobility group box 2
Macaque
high mobility group box 2
Mouse
Rat
Dog
high mobility group box 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P26583-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Programmed Cell Death
Gene Ontology Terms (61)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Genetic Interaction (IGI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
AgBase
Protein-Protein Interactions (113)
1 – 10 of 113
HMGB1
Tbio
Family: TF
Novelty: 0.00043845
Score: 0.998
Data Source: STRINGDB
SET
Tbio
Novelty: 0.01012327
Score: 0.974
Data Source: STRINGDB
APEX1
Tchem
Family: Enzyme
Novelty: 0.00037532
Score: 0.961
Data Source: STRINGDB
GZMA
Tbio
Family: Enzyme
Novelty: 0.00322362
Score: 0.958
Data Source: STRINGDB
ANP32A
Tbio
Novelty: 0.00567095
Score: 0.955
Data Source: STRINGDB
NME1
Tbio
Family: Kinase
Novelty: 0.00103216
Score: 0.942
Data Source: STRINGDB
H1F0
Tchem
Novelty: 0.00039686
Score: 0.926
Data Source: STRINGDB
HIST1H1C
Tbio
Novelty: 0.00415337
Score: 0.924
Data Source: STRINGDB
HIST1H1A
Tbio
Novelty: 0.00123818
Score: 0.923
Data Source: STRINGDB
HIST1H1D
Tbio
Novelty: 0.00922175
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.60

PubMed score by year
PubTator Score  170.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer