Protein Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
- ENST00000354332
- ENSP00000346294
- ENSG00000196154
- ENST00000368714
- ENSP00000357703
- ENST00000368715
- ENSP00000357704
- ENST00000368716
- ENSP00000357705
- CAPL
- MTS1
- 42A
- 18A2
- CAPL
- FSP1
- MTS1
- P9KA
- PEL98
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
biological term | 0.97 | ||
transcription factor perturbation | 0.94 | ||
kinase perturbation | 0.91 | ||
disease perturbation | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 886.42 (req: < 5)
Gene RIFs: 248 (req: <= 3)
Antibodies: 803 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 886.42 (req: >= 5)
Gene RIFs: 248 (req: > 3)
Antibodies: 803 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 11
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (11)
Protein-Protein Interactions (172)
CCDC28A
Novelty: 0.47441753
p_int: 0.999999281
p_ni: 5.42e-7
p_wrong: 1.77e-7
Data Source: BioPlex
SSNA1
Novelty: 0.02189473
p_int: 0.999994062
p_ni: 0.000005925
p_wrong: 1.2e-8
Data Source: BioPlex
CCDC28B
Novelty: 0.16787198
p_int: 0.999992734
p_ni: 0.000007019
p_wrong: 2.47e-7
Data Source: BioPlex
TXNIP
Novelty: 0.00216952
p_int: 0.999984834
p_ni: 0.000015029
p_wrong: 1.36e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
PPFIBP1
Novelty: 0.09685089
p_int: 0.999972179
p_ni: 0.000027821
Score: 0.57
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
WikiPathways (5)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
WikiPathways | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
WikiPathways | Vitamin D Receptor Pathway | ||||
WikiPathways | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway | ||||
WikiPathways | PI3K-Akt Signaling Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
Vitamin D Receptor Pathway | ||||
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway | ||||
PI3K-Akt Signaling Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (7)
Components (6)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet crit | 1 | 1 | 1 | 24.4 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 6.9 | |||||
sleep duration | 1 | 1 | 1 | 6.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet crit | 1 | 24.4 | |||||
high density lipoprotein cholesterol measurement | 1 | 6.9 | |||||
sleep duration | 1 | 6.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | S100 calcium binding protein A4 | VGNC:1527 | 457320 | |||||
Macaque | S100 calcium binding protein A4 | 715115 | ||||||
Mouse | MGI:1330282 | 20198 | ||||||
Rat | RGD:3245 | 24615 | ||||||
Dog | S100 calcium binding protein A4 | VGNC:45830 | 403787 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | S100 calcium binding protein A4 | |||||
Macaque | S100 calcium binding protein A4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | S100 calcium binding protein A4 | |||||
Publication Statistics
PubMed Score 886.42
PubMed score by year
PubTator Score 418.77
PubTator score by year
Related Publications
Text Mined References (293)
GeneRif Annotations (248)
Items per page:
0 of 0
PMID | Year | Title |
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