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Tchem
S100A4
Protein S100-A4

Protein Summary
Description
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354332
  • ENSP00000346294
  • ENSG00000196154
  • ENST00000368714
  • ENSP00000357703
  • ENST00000368715
  • ENSP00000357704
  • ENST00000368716
  • ENSP00000357705

Symbol
  • CAPL
  • MTS1
  • 42A
  • 18A2
  • CAPL
  • FSP1
  • MTS1
  • P9KA
  • PEL98
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
biological term
0.97
transcription factor perturbation
0.94
kinase perturbation
0.91
disease perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 886.42   (req: < 5)
Gene RIFs: 248   (req: <= 3)
Antibodies: 803   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 886.42   (req: >= 5)
Gene RIFs: 248   (req: > 3)
Antibodies: 803   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (172)
MYL12A
Tbio
Novelty:  0.00944255
p_int:  0.999999995
p_wrong:  5e-9
Data Source:  BioPlex
DIAPH3
Tbio
Novelty:  0.01165283
p_int:  0.999999487
p_ni:  5.13e-7
Data Source:  BioPlex
CCDC28A
Tdark
Novelty:  0.47441753
p_int:  0.999999281
p_ni:  5.42e-7
p_wrong:  1.77e-7
Data Source:  BioPlex
KIF18B
Tbio
Novelty:  0.06496349
p_int:  0.999995642
p_ni:  0.000004358
Data Source:  BioPlex
SSNA1
Tbio
Novelty:  0.02189473
p_int:  0.999994062
p_ni:  0.000005925
p_wrong:  1.2e-8
Data Source:  BioPlex
CCDC28B
Tbio
Novelty:  0.16787198
p_int:  0.999992734
p_ni:  0.000007019
p_wrong:  2.47e-7
Data Source:  BioPlex
TXNIP
Tbio
Novelty:  0.00216952
p_int:  0.999984834
p_ni:  0.000015029
p_wrong:  1.36e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
PPFIBP1
Tbio
Novelty:  0.09685089
p_int:  0.999972179
p_ni:  0.000027821
Score:  0.57
Data Source:  BioPlex,STRINGDB
SATB2
Tbio
Family:  TF
Novelty:  0.00405935
p_int:  0.999968789
p_ni:  0.000031211
Data Source:  BioPlex
GAN
Tbio
Novelty:  0.01069743
p_int:  0.999926879
p_ni:  0.000073121
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WikiPathways
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
WikiPathways
PI3K-Akt Signaling Pathway
Name
Explore in Pharos
Explore in Source
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Vitamin D Receptor Pathway
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
PI3K-Akt Signaling Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
24.4
high density lipoprotein cholesterol measurement
1
1
1
6.9
sleep duration
1
1
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
24.4
high density lipoprotein cholesterol measurement
1
6.9
sleep duration
1
6.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A4
VGNC:1527
457320
Macaque
S100 calcium binding protein A4
715115
Mouse
MGI:1330282
20198
Rat
RGD:3245
24615
Dog
S100 calcium binding protein A4
VGNC:45830
403787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A4
Macaque
S100 calcium binding protein A4
Mouse
Rat
Dog
S100 calcium binding protein A4
Publication Statistics
PubMed Score 886.42
PubMed score by year
PubTator Score 418.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title