Tbio S100A4 Protein S100-A4

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Protein S100-a4

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Protein S100-a4

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Protein S100-a4

Protein Summary

Description

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P26447
• A8K7R8
• D3DV46
• Q6ICP8

Gene Name

• S100A4

Ensembl ID

• ENST00000354332
• ENSP00000346294
• ENSG00000196154
• ENST00000368714
• ENSP00000357703
• ENST00000368715
• ENSP00000357704
• ENST00000368716
• ENSP00000357705

Symbol

• CAPL
• MTS1
• 42A
• 18A2
• CAPL
• FSP1
• MTS1
• P9KA
• PEL98

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
biological term	0.97
transcription factor perturbation	0.94
kinase perturbation	0.91
disease perturbation	0.9

Related Tools

GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 811.94   (req: < 5)

Gene RIFs: 248   (req: <= 3)

Antibodies: 803   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 811.94   (req: >= 5)

Gene RIFs: 248   (req: > 3)

Antibodies: 803   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	S100 calcium binding protein A4	VGNC:1527	457320
Macaque	S100 calcium binding protein A4		715115
Mouse	S100 calcium binding protein A4	MGI:1330282	20198
Rat	S100 calcium-binding protein A4	RGD:3245	24615
Dog	S100 calcium binding protein A4	VGNC:45830	403787

Species	Name	OMA	EggNOG	Inparanoid
Chimp	S100 calcium binding protein A4
Macaque	S100 calcium binding protein A4
Mouse	S100 calcium binding protein A4
Rat	S100 calcium-binding protein A4
Dog	S100 calcium binding protein A4

Protein Structure (14 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P26447-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (5)

WikiPathways (5)

Find Similar Targets

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)	285 targets	WP2840_r104845
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)	285 targets	WP2840_r104845
WikiPathways	Vitamin D Receptor Pathway	903 targets	WP2877_r105854
WikiPathways	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	2650 targets	WP3932_r105465
WikiPathways	PI3K-Akt Signaling Pathway	3614 targets	WP4172_r105775

Name	Explore in Pharos	Explore in Source
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)	285 targets	WP2840_r104845
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)	285 targets	WP2840_r104845
Vitamin D Receptor Pathway	903 targets	WP2877_r105854
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	2650 targets	WP3932_r105465
PI3K-Akt Signaling Pathway	3614 targets	WP4172_r105775

Gene Ontology Terms (15)

Functions (7)

Components (6)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
RAGE receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
calcium ion binding	Traceable Author Statement (TAS)	ProtInc
actin binding	Inferred from Electronic Annotation (IEA)	Ensembl
calcium-dependent protein binding	Inferred from Electronic Annotation (IEA)	Ensembl
transition metal ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (172)

Explore Interacting Targets

1 – 10 of 172

• See Interactions on String-DB

MYL12A

Tbio

Novelty: 0.00944255

p_int: 0.999999995

p_wrong: 5e-9

Data Source: BioPlex

DIAPH3

Tbio

Novelty: 0.01165283

p_int: 0.999999487

p_ni: 5.13e-7

Data Source: BioPlex

CCDC28A

Tdark

Novelty: 0.47441753

p_int: 0.999999281

p_ni: 5.42e-7

p_wrong: 1.77e-7

Data Source: BioPlex

KIF18B

Tbio

Novelty: 0.06496349

p_int: 0.999995642

p_ni: 0.000004358

Data Source: BioPlex

SSNA1

Tbio

Novelty: 0.02189473

p_int: 0.999994062

p_ni: 0.000005925

p_wrong: 1.2e-8

Data Source: BioPlex

CCDC28B

Tbio

Novelty: 0.16787198

p_int: 0.999992734

p_ni: 0.000007019

p_wrong: 2.47e-7

Data Source: BioPlex

TXNIP

Tbio

Novelty: 0.00216952

p_int: 0.999984834

p_ni: 0.000015029

p_wrong: 1.36e-7

Score: 0.188

Data Source: BioPlex,STRINGDB

PPFIBP1

Tbio

Novelty: 0.09685089

p_int: 0.999972179

p_ni: 0.000027821

Score: 0.57

Data Source: BioPlex,STRINGDB

SATB2

Tbio

Family: TF

Novelty: 0.00405935

p_int: 0.999968789

p_ni: 0.000031211

Data Source: BioPlex

GAN

Tbio

Novelty: 0.01069743

p_int: 0.999926879

p_ni: 0.000073121

Data Source: BioPlex

Publication Statistics

PubMed Score  811.94

PubMed score by year

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PubTator Score  418.77

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Calcium
Complete proteome
Direct protein sequencing
Metal-binding
Reference proteome
Repeat

MGI Phenotype Find Similar Targets

cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype
mortality/aging
neoplasm
respiratory system phenotype