S100A4
Protein S100-A4
Protein Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
- ENST00000354332
- ENSP00000346294
- ENSG00000196154
- ENST00000368714
- ENSP00000357703
- ENST00000368715
- ENSP00000357704
- ENST00000368716
- ENSP00000357705
- CAPL
- MTS1
- 42A
- 18A2
- CAPL
- FSP1
- MTS1
- P9KA
- PEL98
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
biological term | 0.97 | ||
transcription factor perturbation | 0.94 | ||
kinase perturbation | 0.91 | ||
disease perturbation | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1006.26 (req: < 5)
Gene RIFs: 309 (req: <= 3)
Antibodies: 803 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1006.26 (req: >= 5)
Gene RIFs: 309 (req: > 3)
Antibodies: 803 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 11
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2