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Tbio
CNTF
Ciliary neurotrophic factor

Protein Classes
Protein Summary
Description
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361987
  • ENSP00000355370
  • ENSG00000242689

Symbol
  • HCNTF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
biological process
0.74
biological term
0.65
disease
0.61
chemical
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1201.4   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 594   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1201.4   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 594   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Reactome
Interleukin-6 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IL-6-type cytokine receptor ligand interactions
Immune System
Interleukin-6 family signaling
Signaling by Interleukins
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (158)
1 – 10 of 158
CORO7
Tbio
Novelty: 0.14307384
p_int: 0.999961649
p_ni: 0.00003835
Data Source: BioPlex
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
p_int: 0.993198088
p_ni: 0.006801911
Score: 0.239
Data Source: BioPlex,STRINGDB
RBM12
Tbio
Novelty: 0.10430477
p_int: 0.847211044
p_ni: 0.152784059
p_wrong: 0.000004897
Score: 0.187
Data Source: BioPlex,STRINGDB
FEM1B
Tbio
Novelty: 0.06746412
p_int: 0.773296574
p_ni: 0.226703426
Data Source: BioPlex
CNTFR
Tbio
Novelty: 0.0188716
Score: 0.994
Data Source: Reactome,STRINGDB
LIFR
Tbio
Novelty: 0.00514085
Score: 0.985
Data Source: Reactome,STRINGDB
IL6ST
Tclin
Novelty: 0.01026472
Score: 0.974
Data Source: Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.952
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.945
Data Source: Reactome,STRINGDB
LEP
Tbio
Novelty: 0.00005295
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  1201.40

PubMed score by year
PubTator Score  428.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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