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Tbio
IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

Protein Summary
Description
Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000479013
  • ENSP00000417990
  • ENSG00000128928
  • ENST00000487418
  • ENSP00000418397

Symbol
  • ACAD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.99
kinase perturbation
0.96
gene perturbation
0.74
protein domain
0.73


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Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GlyGen
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.68   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.68   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
95.9
intelligence
3
2
1
5.6
90.7
blood metabolite measurement
2
1
2
86.1
cognitive function measurement
3
2
3
79.5
1
1
0
1.3
79.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
95.9
intelligence
1
5.6
90.7
blood metabolite measurement
2
86.1
cognitive function measurement
3
79.5
0
1.3
79.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
isovaleryl-CoA dehydrogenase
VGNC:11918
453333
Macaque
isovaleryl-CoA dehydrogenase [Source:HGNC Symbol;Acc:HGNC:6186]
Mouse
MGI:1929242
56357
Rat
RGD:2936
24513
Dog
isovaleryl-CoA dehydrogenase
100856316
Species
Name
OMA
EggNOG
Inparanoid
Chimp
isovaleryl-CoA dehydrogenase
Macaque
isovaleryl-CoA dehydrogenase [Source:HGNC Symbol;Acc:HGNC:6186]
Mouse
Rat
Dog
isovaleryl-CoA dehydrogenase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P26440-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Metabolism
Metabolism of amino acids and derivatives
Protein-Protein Interactions (82)
1 – 10 of 82
KIR3DL2
Tbio
Novelty: 0.00321353
p_int: 0.995246662
p_ni: 0.004753338
Score: 0.204
Data Source: BioPlex,STRINGDB
STK11
Tchem
Family: Kinase
Novelty: 0.00073247
p_int: 0.888808564
p_ni: 0.111191436
Score: 0.379
Data Source: BioPlex,STRINGDB
MCCC2
Tbio
Family: Enzyme
Novelty: 0.06681335
Score: 0.991
Data Source: STRINGDB
MCCC1
Tbio
Family: Enzyme
Novelty: 0.01234441
Score: 0.962
Data Source: STRINGDB
ECHS1
Tbio
Family: Enzyme
Novelty: 0.01291476
Score: 0.955
Data Source: STRINGDB
DBT
Tbio
Family: Enzyme
Novelty: 0.0070589
Score: 0.954
Data Source: STRINGDB
BCKDHB
Tbio
Family: Enzyme
Novelty: 0.02234969
Score: 0.953
Data Source: STRINGDB
BCKDHA
Tbio
Family: Enzyme
Novelty: 0.01684893
Score: 0.949
Data Source: STRINGDB
HADHA
Tbio
Novelty: 0.00385746
Score: 0.948
Data Source: STRINGDB
EHHADH
Tbio
Novelty: 0.00878193
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.68

PubMed score by year
PubTator Score  83.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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