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Tclin
HSD3B2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Protein Classes
Protein Summary
Description
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369416
  • ENSP00000358424
  • ENSG00000203859
  • ENST00000543831
  • ENSP00000445122

Symbol
  • HSDB3B
  • HSDB
  • HSD3B
  • SDR11E2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
gene perturbation
0.85
cellular component
0.71
disease
0.7
biological term
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.2   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.2   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
trilostane
Rendered image for trilostane
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
4
4
68
waist circumference
1
3
3
52.3
folding of antihelix
1
1
1
50.6
antitragus size
1
1
1
21.5
testosterone measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
4
68
waist circumference
3
52.3
folding of antihelix
1
50.6
antitragus size
1
21.5
testosterone measurement
1
17.8
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
457165
Species
Name
OMA
EggNOG
Inparanoid
Chimp
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P26439-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Androgen biosynthesis (R-HSA-193048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Androgen biosynthesis
Reactome
Glucocorticoid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Name
Explore in Pharos
Explore in Source
Androgen biosynthesis
Glucocorticoid biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (114)
1 – 10 of 114
HSD3B1
Tchem
Family:  Enzyme
Novelty:  0.0019271
p_int:  1
Score:  0.933
Data Source:  BioPlex,STRINGDB
TMEM38A
Tbio
Family:  IC
Novelty:  0.10891929
p_int:  0.999999982
p_wrong:  1.7e-8
Data Source:  BioPlex
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
p_int:  0.999999625
p_ni:  3.75e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
TOP2B
Tclin
Family:  Enzyme
Novelty:  0.00647819
p_int:  0.999977552
p_ni:  0.000022381
p_wrong:  6.7e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
TOP2A
Tclin
Family:  Enzyme
Novelty:  0.00122788
p_int:  0.999582935
p_ni:  0.000417012
p_wrong:  5.4e-8
Score:  0.172
Data Source:  BioPlex,STRINGDB
CTSF
Tchem
Family:  Enzyme
Novelty:  0.01359417
p_int:  0.999371759
p_ni:  0.00062824
p_wrong:  1e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
WBP11
Tbio
Novelty:  0.03891455
p_int:  0.995084434
p_ni:  0.004884971
p_wrong:  0.000030595
Score:  0.165
Data Source:  BioPlex,STRINGDB
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
p_int:  0.983553598
p_ni:  0.016446402
Score:  0.223
Data Source:  BioPlex,STRINGDB
H2AFY
Tbio
Novelty:  0.01150729
p_int:  0.968854238
p_ni:  0.031145762
Score:  0.166
Data Source:  BioPlex,STRINGDB
LETM1
Tbio
Novelty:  0.01542461
p_int:  0.963164664
p_ni:  0.025686344
p_wrong:  0.011148992
Score:  0.183
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  137.20

PubMed score by year
PubTator Score  90.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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