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Tbio
ELAVL4
ELAV-like protein 4

Protein Summary
Description
May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371823
  • ENSP00000360888
  • ENSG00000162374
  • ENST00000371824
  • ENSP00000360889
  • ENST00000371827
  • ENSP00000360892
  • ENST00000448907
  • ENSP00000399939

Symbol
  • HUD
  • PNEM
  • HUD
  • PNEM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.82
cellular component
0.66
virus perturbation
0.64
PubMedID
0.61
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.89   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.89   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
1
1
0
1
93.6
smoking status measurement
1
1
1
86.4
body mass index
3
1
4
86
smoking initiation
1
1
1
80.9
cigarettes per day measurement
1
1
1
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
unipolar depression
0
1
93.6
smoking status measurement
1
86.4
body mass index
4
86
smoking initiation
1
80.9
cigarettes per day measurement
1
70.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ELAV like RNA binding protein 4
VGNC:14403
735317
Macaque
ELAV like RNA binding protein 4
711231
Mouse
MGI:107427
15572
Rat
RGD:1560027
432358
Dog
ELAV like RNA binding protein 4
VGNC:54201
475361
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ELAV like RNA binding protein 4
Macaque
ELAV like RNA binding protein 4
Mouse
Rat
Dog
ELAV like RNA binding protein 4
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P26378-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (140)
1 – 10 of 140
RPL23A
Tbio
Novelty: 0.02951947
p_int: 0.999587176
p_ni: 0.000406485
p_wrong: 0.000006339
Data Source: BioPlex
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.997873097
p_ni: 0.001924001
p_wrong: 0.000202902
Score: 0.181
Data Source: BioPlex,STRINGDB
SART3
Tbio
Novelty: 0.02353492
p_int: 0.988373382
p_ni: 0.011607223
p_wrong: 0.000019395
Data Source: BioPlex
STAU1
Tbio
Novelty: 0.00565778
p_int: 0.983526793
p_ni: 0.016435381
p_wrong: 0.000037826
Score: 0.572
Data Source: BioPlex,STRINGDB
SYNCRIP
Tbio
Novelty: 0.01479381
p_int: 0.871108876
p_ni: 0.001418999
p_wrong: 0.127472125
Score: 0.323
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.871108876
p_ni: 0.001418999
p_wrong: 0.127472125
Data Source: BioPlex
RNF41
Tbio
Family: Enzyme
Novelty: 0.01953473
p_int: 0.80301051
p_ni: 0.000428444
p_wrong: 0.196561046
Data Source: BioPlex
LGALS4
Tchem
Novelty: 0.00021923
Score: 0.923
Data Source: STRINGDB
IGF2BP1
Tbio
Novelty: 0.00830935
Score: 0.81
Data Source: STRINGDB
GAP43
Tbio
Novelty: 0.00091023
Score: 0.803
Data Source: STRINGDB
Publication Statistics
PubMed Score  357.89

PubMed score by year
PubTator Score  23.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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