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Tbio
RPL13
60S ribosomal protein L13

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311528
  • ENSP00000307889
  • ENSG00000167526
  • ENST00000393099
  • ENSP00000376811
  • ENST00000452368
  • ENSP00000438959
  • ENST00000567815
  • ENSP00000455009

Symbol
  • BBC1
  • L13
  • BBC1
  • D16S44E
  • D16S444E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
transcription factor perturbation
1
hub protein
0.99
kinase perturbation
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.16   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.16   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
4
4
98.9
hair color
1
2
0
6.4
92.9
homocysteine measurement
2
2
2
92.3
glomerular filtration rate
5
4
5
92
1
1
1
86
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
4
98.9
hair color
0
6.4
92.9
homocysteine measurement
2
92.3
glomerular filtration rate
5
92
1
86
Orthologs (18)
1 – 5 of 18
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L13
VGNC:5912
454316
Macaque
ribosomal protein L13
700603
Mouse
MGI:105922
270106
Rat
RGD:621179
81765
Dog
ribosomal protein L13
VGNC:53438
479612
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L13
Macaque
ribosomal protein L13
Mouse
Rat
Dog
ribosomal protein L13
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P26373-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (478)
1 – 10 of 478
TUBA8
Tbio
Novelty:  0.06454549
p_int:  0.999999791
p_ni:  2.09e-7
Score:  0.34
Data Source:  BioPlex,STRINGDB
NSUN4
Tbio
Family:  Enzyme
Novelty:  0.15593771
p_int:  0.994421013
p_ni:  0.005578031
p_wrong:  9.56e-7
Score:  0.39
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.991133123
p_ni:  0.008845893
p_wrong:  0.000020984
Score:  0.281
Data Source:  BioPlex,STRINGDB
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.957317148
p_ni:  0.042682852
Score:  0.397
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.954883592
p_ni:  0.045116408
Data Source:  BioPlex
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.932315995
p_ni:  0.067684005
Data Source:  BioPlex
MRPL28
Tdark
Novelty:  0.23845162
p_int:  0.921047217
p_ni:  0.078952783
Score:  0.665
Data Source:  BioPlex,STRINGDB
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.920492748
p_ni:  0.079507252
Score:  0.569
Data Source:  BioPlex,STRINGDB
SART3
Tbio
Novelty:  0.02353492
p_int:  0.915676087
p_ni:  0.084323913
Data Source:  BioPlex
MRPL27
Tdark
Novelty:  0.15636105
p_int:  0.913717733
p_ni:  0.086282267
Score:  0.545
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  58.16

PubMed score by year
PubTator Score  29.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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