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Tbio
PAX6
Paired box protein Pax-6

Protein Summary
Description
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes. This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundred ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241001
  • ENSP00000241001
  • ENSG00000007372
  • ENST00000379107
  • ENSP00000368401
  • ENST00000379109
  • ENSP00000368403
  • ENST00000379129
  • ENSP00000368424
  • ENST00000379132
  • ENSP00000368427
  • ENST00000419022
  • ENSP00000404100
  • ENST00000606377
  • ENSP00000480026
  • ENST00000638903
  • ENSP00000492296
  • ENST00000638914
  • ENSP00000492315
  • ENST00000639409
  • ENSP00000492476
  • ENST00000639916
  • ENSP00000490963
  • ENST00000640287
  • ENSP00000492822
  • ENST00000640368
  • ENSP00000492024
  • ENST00000640610
  • ENSP00000491295
  • ENST00000640975
  • ENSP00000491872
  • ENST00000643871
  • ENSP00000495109
  • ENST00000645710
  • ENSP00000494722

Symbol
  • AN2
  • AN
  • AN2
  • FVH1
  • MGDA
  • WAGR
  • ASGD5
  • D11S812E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
co-expressed gene
0.97
kinase perturbation
0.96
PubMedID
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1863.71   (req: < 5)
Gene RIFs: 243   (req: <= 3)
Antibodies: 851   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1863.71   (req: >= 5)
Gene RIFs: 243   (req: > 3)
Antibodies: 851   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 70
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0