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Tclin
DNMT1
DNA (cytosine-5)-methyltransferase 1

Protein Summary
Description
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to mainta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340748
  • ENSP00000345739
  • ENSG00000130816
  • ENST00000359526
  • ENSP00000352516

Symbol
  • AIM
  • CXXC9
  • DNMT
  • AIM
  • DNMT
  • MCMT
  • CXXC9
  • HSN1E
  • ADCADN
  • m.HsaI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
disease perturbation
0.93
chemical
0.92
kinase
0.92
biological process
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2574.41   (req: < 5)
Gene RIFs: 449   (req: <= 3)
Antibodies: 1477   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2574.41   (req: >= 5)
Gene RIFs: 449   (req: > 3)
Antibodies: 1477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
1
2
78.6
monocyte count
1
1
1
73
reticulocyte count
6
4
8
72.9
reticulocyte measurement
3
3
6
67
birth weight
1
1
1
21.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
78.6
monocyte count
1
73
reticulocyte count
8
72.9
reticulocyte measurement
6
67
birth weight
1
21.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA methyltransferase 1
VGNC:10201
107969662
Macaque
DNA methyltransferase 1
574321
Mouse
MGI:94912
13433
Rat
RGD:620979
84350
Dog
DNA methyltransferase 1
476715
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA methyltransferase 1
Macaque
DNA methyltransferase 1
Mouse
Rat
Dog
DNA methyltransferase 1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P26358-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
DNA methylation (R-HSA-5334118)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA methylation
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Metabolism of proteins
Reactome
Negative epigenetic regulation of rRNA expression
Name
Explore in Pharos
Explore in Source
DNA methylation
Epigenetic regulation of gene expression
Gene expression (Transcription)
Metabolism of proteins
Negative epigenetic regulation of rRNA expression
Gene Ontology Terms (30)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (438)
1 – 10 of 438
DMAP1
Tbio
Family: Enzyme
Novelty: 0.03152166
p_int: 0.9999959
p_ni: 0.0000041
Score: 0.882
Data Source: BioPlex,STRINGDB
DNMT3B
Tchem
Family: Epigenetic
Novelty: 0.00118766
Score: 0.998
Data Source: STRINGDB
DNMT3A
Tclin
Family: Epigenetic
Novelty: 0.00085974
Score: 0.996
Data Source: STRINGDB
UHRF1
Tbio
Family: Epigenetic
Novelty: 0.00482565
Score: 0.996
Data Source: Reactome,STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.994
Data Source: Reactome,STRINGDB
RB1
Tchem
Novelty: 0.00063798
Score: 0.992
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.99
Data Source: STRINGDB
HDAC2
Tclin
Family: Epigenetic
Novelty: 0.0011024
Score: 0.986
Data Source: STRINGDB
SMARCA5
Tbio
Novelty: 0.00518484
Score: 0.982
Data Source: STRINGDB
MBD2
Tchem
Family: TF
Novelty: 0.01209635
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  2574.41

PubMed score by year
PubTator Score  1375.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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