Tclin DNMT1 DNA (cytosine-5)-methyltransferase 1

Protein Summary

Description

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). Promotes tumor growth (PubMed:24623306). This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P26358
• A0AV63
• B7ZLW6
• Q9UHG5
• Q9ULA2
• Q9UMZ6
• Dnmt1

Gene Name

• DNMT1

Ensembl ID

• ENST00000340748
• ENSP00000345739
• ENSG00000130816
• ENST00000359526
• ENSP00000352516

Symbol

• AIM
• CXXC9
• DNMT
• AIM
• DNMT
• MCMT
• CXXC9
• HSN1E
• ADCADN
• m.HsaI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
disease perturbation	0.93
chemical	0.92
kinase	0.92
biological process	0.9

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Writer / Dna Methyltransferase / Dna (Cytosine-5)-methyltransferase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3028.83   (req: < 5)

Gene RIFs: 601   (req: <= 3)

Antibodies: 1477   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3028.83   (req: >= 5)

Gene RIFs: 601   (req: > 3)

Antibodies: 1477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 81

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2