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Tbio
CTNNA2
Catenin alpha-2

Protein Summary
Description
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343114
  • ENSP00000341500
  • ENSG00000066032
  • ENST00000402739
  • ENSP00000384638
  • ENST00000466387
  • ENSP00000418191
  • ENST00000496558
  • ENSP00000419295
  • ENST00000541047
  • ENSP00000444675
  • ENST00000629316
  • ENSP00000486160

Symbol
  • CAPR
  • CAPR
  • CTNR
  • CAP-R
  • CT114
  • CDCBM9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
gene perturbation
0.9
hub protein
0.75
kinase
0.72
disease
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.32   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.32   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
88.8
self reported educational attainment
1
3
3
88.4
smoking status measurement
2
3
3
79.2
cognitive function measurement
1
2
2
67.7
1
1
1
45.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
88.8
self reported educational attainment
3
88.4
smoking status measurement
3
79.2
cognitive function measurement
2
67.7
1
45.8
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
catenin alpha 2
712135
Mouse
MGI:88275
12386
Zebrafish
ZDB-GENE-060815-3
567500
C. elegans
179624
Fruitfly
FBgn0010215
40517
Species
Name
OMA
EggNOG
Inparanoid
Macaque
catenin alpha 2
Mouse
Zebrafish
C. elegans
Fruitfly
Pathways (81)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Myogenesis
Name
Explore in Pharos
Explore in Source
Developmental Biology
Myogenesis
Protein-Protein Interactions (148)
1 – 10 of 148
CTNNA1
Tbio
Novelty: 0.00925774
p_int: 0.999999907
p_ni: 9.3e-8
Score: 0.902
Data Source: BioPlex,Reactome,STRINGDB
CDH8
Tbio
Novelty: 0.04055999
p_int: 0.999998846
p_ni: 0.000001154
Score: 0.453
Data Source: BioPlex,STRINGDB
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.999967386
p_ni: 0.000032614
Score: 0.27
Data Source: BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty: 0.01605171
p_int: 0.9984685
p_ni: 0.0015315
Data Source: BioPlex
CTNNBIP1
Tbio
Novelty: 0.05434645
p_int: 0.988060015
p_ni: 0.011939983
p_wrong: 2e-9
Score: 0.42
Data Source: BioPlex,STRINGDB
SAPCD1
Tdark
Novelty: 0.90892824
p_int: 0.967680243
p_ni: 0.032319033
p_wrong: 7.24e-7
Score: 0.252
Data Source: BioPlex,STRINGDB
CD27
Tbio
Novelty: 0.00090508
p_int: 0.894352128
p_ni: 0.105647871
p_wrong: 1e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
DUSP22
Tbio
Family: Enzyme
Novelty: 0.01579003
p_int: 0.877116344
p_ni: 0.122883655
p_wrong: 1e-9
Data Source: BioPlex
FBXL5
Tbio
Novelty: 0.03103624
p_int: 0.843515069
p_ni: 0.15648493
Score: 0.183
Data Source: BioPlex,STRINGDB
CIR1
Tdark
Novelty: 0.31735301
p_int: 0.838129021
p_ni: 0.161870977
p_wrong: 2e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  135.32

PubMed score by year
PubTator Score  19.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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