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Tbio
DDX6
Probable ATP-dependent RNA helicase DDX6

Protein Summary
Description
In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573). This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000526070
  • ENSP00000433704
  • ENSG00000110367
  • ENST00000534980
  • ENSP00000442266
  • ENST00000620157
  • ENSP00000478754

Symbol
  • HLR2
  • RCK
  • P54
  • RCK
  • HLR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
1
molecular function
0.96
small molecule perturbation
0.94
microRNA
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.77   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.77   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
57.1
body height
1
1
1
26
monocyte percentage of leukocytes
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
57.1
body height
1
26
monocyte percentage of leukocytes
1
25.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DEAD-box helicase 6
701441
Mouse
MGI:104976
13209
Rat
RGD:1564560
500988
Dog
DEAD-box helicase 6
VGNC:39869
479414
Horse
DEAD-box helicase 6
VGNC:17108
100063116
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DEAD-box helicase 6
Mouse
Rat
Dog
DEAD-box helicase 6
Horse
DEAD-box helicase 6
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P26196-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
mRNA decay by 5' to 3' exoribonuclease
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
mRNA decay by 5' to 3' exoribonuclease
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (253)
1 – 10 of 253
EDC3
Tbio
Novelty: 0.02077346
p_int: 0.999999977
p_ni: 2.3e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
DCP1B
Tdark
Novelty: 0.36605365
p_int: 0.999999853
p_ni: 1.47e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
EDC4
Tbio
Novelty: 0.00365253
p_int: 0.999881571
p_ni: 0.000118429
Score: 0.996
Data Source: BioPlex,STRINGDB
DCP1A
Tbio
Novelty: 0.02038933
p_int: 0.99917662
p_ni: 0.00082338
Score: 0.999
Data Source: BioPlex,STRINGDB
MCRIP2
Tdark
Novelty: 1.50465727
p_int: 0.998861216
p_ni: 0.001138784
Score: 0.429
Data Source: BioPlex,STRINGDB
ATXN2
Tbio
Novelty: 0.00373116
p_int: 0.998019598
p_ni: 0.001980402
Score: 0.877
Data Source: BioPlex,STRINGDB
NUFIP2
Tbio
Novelty: 0.09366649
p_int: 0.993308522
p_ni: 0.006691478
Score: 0.795
Data Source: BioPlex,STRINGDB
PNLIPRP2
Tbio
Family: Enzyme
p_int: 0.988693896
p_ni: 0.011306104
Data Source: BioPlex
PNRC1
Tbio
Novelty: 0.00705875
p_int: 0.9729392
p_ni: 4.5e-8
p_wrong: 0.027060755
Score: 0.519
Data Source: BioPlex,STRINGDB
PIM1
Tchem
Family: Kinase
Novelty: 0.0049837
p_int: 0.936654222
p_ni: 0.063345778
Score: 0.873
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  98.77

PubMed score by year
PubTator Score  39.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer