Tbio DDX6 Probable ATP-dependent RNA helicase DDX6

Protein Summary

Description

In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573). This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• P26196
• Q5D048

Gene Name

• DDX6

Ensembl ID

• ENST00000526070
• ENSP00000433704
• ENSG00000110367
• ENST00000534980
• ENSP00000442266
• ENST00000620157
• ENSP00000478754

Symbol

• HLR2
• RCK
• P54
• RCK
• HLR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
virus perturbation	1
molecular function	0.96
small molecule perturbation	0.94
microRNA	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.97   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 393   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.97   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0