Tbio PTPN3 Tyrosine-protein phosphatase non-receptor type 3

Protein Summary

Description

May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• P26045
• A0AUW9
• E7EN99
• E9PGU7

Gene Name

• PTPN3

Ensembl ID

• ENST00000374541
• ENSP00000363667
• ENSG00000070159
• ENST00000412145
• ENSP00000416654
• ENST00000446349
• ENSP00000395384

Symbol

• PTPH1
• PTPH1
• PTP-H1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
disease perturbation	0.96
virus perturbation	0.72
microRNA	0.67
molecular function	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.06   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.06   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0