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Tbio
PTX3
Pentraxin-related protein PTX3

Protein Summary
Description
Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295927
  • ENSP00000295927
  • ENSG00000163661

Symbol
  • TNFAIP5
  • TSG14
  • TSG-14
  • TNFAIP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological term
0.99
gene perturbation
0.98
PubMedID
0.96
small molecule perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 889.05   (req: < 5)
Gene RIFs: 309   (req: <= 3)
Antibodies: 420   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 889.05   (req: >= 5)
Gene RIFs: 309   (req: > 3)
Antibodies: 420   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pentraxin-related protein PTX3 measurement
1
2
2
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pentraxin-related protein PTX3 measurement
2
76.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pentraxin 3
VGNC:2527
460807
Mouse
MGI:104641
19288
Rat
RGD:1593476
689388
Dog
pentraxin 3
VGNC:45204
100685178
Cow
pentraxin 3
VGNC:33566
541148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pentraxin 3
Mouse
Rat
Dog
pentraxin 3
Cow
pentraxin 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P26022-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (149)
1 – 10 of 149
CYB5D2
Tbio
Novelty:  0.23122479
p_int:  0.999999547
p_ni:  4.53e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
ZNF224
Tbio
Family:  TF
Novelty:  0.05381083
p_int:  0.999988437
p_ni:  0.00001137
p_wrong:  1.93e-7
Score:  0.197
Data Source:  BioPlex,STRINGDB
COLEC10
Tbio
Novelty:  0.02593638
p_int:  0.9999762
p_ni:  0.000023799
p_wrong:  1e-9
Score:  0.293
Data Source:  BioPlex,STRINGDB
A2M
Tbio
Novelty:  0.00070446
p_int:  0.99982907
p_ni:  0.000142432
p_wrong:  0.000028498
Score:  0.215
Data Source:  BioPlex,STRINGDB
OR5C1
Tdark
Family:  oGPCR
Novelty:  1.6529517
p_int:  0.998419118
p_ni:  0.001580881
Data Source:  BioPlex
TRMT10B
Tdark
Family:  Enzyme
Novelty:  0.61950381
p_int:  0.997227089
p_ni:  0.000978155
p_wrong:  0.001794756
Score:  0.181
Data Source:  BioPlex,STRINGDB
TNFAIP6
Tbio
Novelty:  0.0046811
Score:  0.988
Data Source:  STRINGDB
CFP
Tbio
Novelty:  0.00063251
Score:  0.949
Data Source:  STRINGDB
MMP9
Tchem
Family:  Enzyme
Novelty:  0.00008645
Score:  0.939
Data Source:  STRINGDB
CXCL1
Tbio
Novelty:  0.00059123
Score:  0.938
Data Source:  STRINGDB
Publication Statistics
PubMed Score  889.05

PubMed score by year
PubTator Score  654.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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