Tbio PTX3 Pentraxin-related protein PTX3

Protein Summary

Description

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]

Uniprot Accession IDs

• P26022
• B2R6T6
• Q38M82

Gene Name

• PTX3

Ensembl ID

• ENST00000295927
• ENSP00000295927
• ENSG00000163661

Symbol

• TNFAIP5
• TSG14
• TSG-14
• TNFAIP5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
biological term	0.99
gene perturbation	0.98
PubMedID	0.96
small molecule perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 953.76   (req: < 5)

Gene RIFs: 446   (req: <= 3)

Antibodies: 420   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 953.76   (req: >= 5)

Gene RIFs: 446   (req: > 3)

Antibodies: 420   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0