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Tbio
ITGB8
Integrin beta-8

Protein Summary
Description
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072). It recognizes the sequence R-G-D in its ligands (PubMed:1918072). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity). This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; ho ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222573
  • ENSP00000222573
  • ENSG00000105855
  • ENST00000537992
  • ENSP00000441561
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
PubMedID
0.93
gene perturbation
0.87
histone modification site profile
0.84
transcription factor binding site profile
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.7   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.7   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
5
5
95.8
BMI-adjusted waist circumference
5
16
19
93.1
eosinophil percentage of leukocytes
1
2
2
87.5
childhood onset asthma
2
3
0
1.1
86.2
3
5
0
1.1
82.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
95.8
BMI-adjusted waist circumference
19
93.1
eosinophil percentage of leukocytes
2
87.5
childhood onset asthma
0
1.1
86.2
0
1.1
82.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 8
VGNC:4407
463282
Macaque
integrin subunit beta 8
707247
Mouse
MGI:1338035
320910
Rat
RGD:1311374
362800
Dog
integrin subunit beta 8
VGNC:42143
475253
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 8
Macaque
integrin subunit beta 8
Mouse
Rat
Dog
integrin subunit beta 8
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P26012-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Integrin cell surface interactions
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Integrin cell surface interactions
Molecules associated with elastic fibres
Gene Ontology Terms (22)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (136)
1 – 10 of 136
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.999996842
p_ni:  0.000003152
p_wrong:  6e-9
Data Source:  BioPlex
ACTR3C
Tdark
Novelty:  0.16443513
p_int:  0.991724574
p_ni:  0.000020853
p_wrong:  0.008254573
Score:  0.236
Data Source:  BioPlex,STRINGDB
LMF1
Tbio
Family:  Enzyme
Novelty:  0.0280811
p_int:  0.98854967
p_ni:  0.01145033
Score:  0.622
Data Source:  BioPlex,STRINGDB
NME4
Tbio
Family:  Kinase
Novelty:  0.03735196
p_int:  0.889265867
p_ni:  0.110734133
Score:  0.571
Data Source:  BioPlex,STRINGDB
L2HGDH
Tbio
Family:  Enzyme
Novelty:  0.01766669
p_int:  0.872775376
p_ni:  0.127224624
Score:  0.188
Data Source:  BioPlex,STRINGDB
WRB
Tbio
Novelty:  0.01267171
p_int:  0.858312923
p_ni:  0.141582575
p_wrong:  0.000104502
Score:  0.314
Data Source:  BioPlex,STRINGDB
B3GNT2
Tbio
Family:  Enzyme
Novelty:  0.02724566
p_int:  0.852723301
p_ni:  0.146721819
p_wrong:  0.000554881
Score:  0.19
Data Source:  BioPlex,STRINGDB
RHBDL1
Tdark
Family:  Enzyme
Novelty:  0.63616927
p_int:  0.83790173
p_ni:  0.162000162
p_wrong:  0.000098108
Score:  0.216
Data Source:  BioPlex,STRINGDB
TIMM29
Tdark
Novelty:  0.51321672
p_int:  0.823224437
p_ni:  0.176205781
p_wrong:  0.000569782
Score:  0.185
Data Source:  BioPlex,STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.996
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  65.70

PubMed score by year
PubTator Score  23.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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