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Tclin
ITGB7
Integrin beta-7

Protein Summary
Description
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin. This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267082
  • ENSP00000267082
  • ENSG00000139626
  • ENST00000422257
  • ENSP00000408741
  • ENST00000550743
  • ENSP00000455374
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
PubMedID
0.83
gene perturbation
0.77
cell type or tissue
0.71
cellular component
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.1   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 484   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.1   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 484   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
natalizumab
no chemical structure image available
vedolizumab
no chemical structure image available
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
61.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
61.5
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Extracellular matrix organization
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Integrin cell surface interactions
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Extracellular matrix organization
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (170)
1 – 10 of 170
ITGA4
Tclin
Novelty: 0.00197607
Score: 0.997
Data Source: Reactome,STRINGDB
FLNA
Tbio
Novelty: 0.00156479
Score: 0.986
Data Source: STRINGDB
ITGAE
Tbio
Novelty: 0.00179591
Score: 0.975
Data Source: Reactome,STRINGDB
ITGAL
Tclin
Novelty: 0.00099016
Score: 0.969
Data Source: STRINGDB
ITGA3
Tchem
Novelty: 0.00505981
Score: 0.969
Data Source: STRINGDB
ITGAV
Tchem
Novelty: 0.00148589
Score: 0.969
Data Source: STRINGDB
MADCAM1
Tbio
Novelty: 0.00325843
Score: 0.968
Data Source: Reactome,STRINGDB
ITGA8
Tbio
Novelty: 0.0220023
Score: 0.967
Data Source: STRINGDB
ITGAD
Tbio
Novelty: 0.01613546
Score: 0.964
Data Source: STRINGDB
ITGA11
Tbio
Novelty: 0.02501472
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.10

PubMed score by year
PubTator Score  26.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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