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Tchem
ITGA3
Integrin alpha-3

Protein Summary
Description
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000007722
  • ENSP00000007722
  • ENSG00000005884
  • ENST00000320031
  • ENSP00000315190

Symbol
  • MSK18
  • VL3A
  • CD49C
  • FRP-2
  • GAPB3
  • ILNEB
  • MSK18
  • VCA-2
  • VLA3a
  • GAP-B3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
biological process
0.91
transcription factor perturbation
0.88
disease perturbation
0.79
cellular component
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.58   (req: < 5)
Gene RIFs: 125   (req: <= 3)
Antibodies: 933   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.58   (req: >= 5)
Gene RIFs: 125   (req: > 3)
Antibodies: 933   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (156)
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999993538
p_ni:  0.000006462
p_wrong:  1e-9
Score:  0.518
Data Source:  BioPlex,STRINGDB
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.999657411
p_ni:  0.0002249
p_wrong:  0.000117689
Score:  0.173
Data Source:  BioPlex,STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.992
Data Source:  Reactome,STRINGDB
ITGB3
Tclin
Novelty:  0.00067255
Score:  0.984
Data Source:  STRINGDB
ITGB5
Tbio
Novelty:  0.01455909
Score:  0.982
Data Source:  STRINGDB
LAMA5
Tbio
Novelty:  0.02247145
Score:  0.981
Data Source:  Reactome,STRINGDB
LAMA3
Tbio
Novelty:  0.00733792
Score:  0.974
Data Source:  Reactome,STRINGDB
ITGB4
Tbio
Novelty:  0.00386461
Score:  0.972
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.969
Data Source:  STRINGDB
ITGB7
Tclin
Novelty:  0.01290005
Score:  0.969
Data Source:  STRINGDB
Nearest Tclin Targets (11)
Explore Nearest Tclin Targets
1 – 5 of 5
ITGB7
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGB1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  10
more:  6 more common pathways
ITGB3
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  9
more:  5 more common pathways
ITGA4
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  9
more:  5 more common pathways
ITGA2B
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  11
more:  7 more common pathways
Pathways (43)
Basigin interactions (R-HSA-210991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Reactome
Integrin cell surface interactions
Name
Explore in Pharos
Explore in Source
Basigin interactions
Cell surface interactions at the vascular wall
Extracellular matrix organization
Hemostasis
Integrin cell surface interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (51)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
5
5
92.2
cup-to-disc ratio measurement
2
2
2
57.2
mathematical ability
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
92.2
cup-to-disc ratio measurement
2
57.2
mathematical ability
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
integrin subunit alpha 3
700962
Mouse
MGI:96602
16400
Rat
RGD:1310333
360606
Dog
integrin subunit alpha 3
VGNC:42125
491074
Horse
integrin subunit alpha 3
VGNC:19164
100056202
Species
Name
OMA
EggNOG
Inparanoid
Macaque
integrin subunit alpha 3
Mouse
Rat
Dog
integrin subunit alpha 3
Horse
integrin subunit alpha 3
Publication Statistics
PubMed Score 190.58
PubMed score by year
PubTator Score 106.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title