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Tchem
CD40
Tumor necrosis factor receptor superfamily member 5

Protein Summary
Description
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affec ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372276
  • ENSP00000361350
  • ENSG00000101017
  • ENST00000372285
  • ENSP00000361359

Symbol
  • TNFRSF5
  • p50
  • Bp50
  • CDW40
  • TNFRSF5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
0.95
disease
0.91
chemical
0.86
PubMedID
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3416.58   (req: < 5)
Gene RIFs: 410   (req: <= 3)
Antibodies: 2479   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3416.58   (req: >= 5)
Gene RIFs: 410   (req: > 3)
Antibodies: 2479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
2
1.1
93.6
tumor necrosis factor, receptor superfamily, member 5 measurement
1
2
2
87.6
chronic hepatitis B virus infection
1
1
0
1.2
76.1
1
1
0
1.1
70.9
neuroticism measurement
1
2
0
5.8
65.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
93.6
tumor necrosis factor, receptor superfamily, member 5 measurement
2
87.6
chronic hepatitis B virus infection
0
1.2
76.1
0
1.1
70.9
neuroticism measurement
0
5.8
65.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
CD40 molecule
707749
Mouse
MGI:88336
21939
Rat
RGD:619830
171369
Dog
CD40 molecule
VGNC:38958
403469
Horse
CD40 molecule
VGNC:16268
100034049
Species
Name
OMA
EggNOG
Inparanoid
Macaque
CD40 molecule
Mouse
Rat
Dog
CD40 molecule
Horse
CD40 molecule
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P25942-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cytokine Signaling in Immune system
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Gene Ontology Terms (48)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (458)
1 – 10 of 458
TRAF3
Tbio
Novelty: 0.0022525
Score: 0.999
Data Source: Reactome,STRINGDB
CD40LG
Tbio
Novelty: 0.00032058
Score: 0.999
Data Source: Reactome,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.995
Data Source: Reactome,STRINGDB
TRAF1
Tbio
Novelty: 0.00526776
Score: 0.994
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.994
Data Source: STRINGDB
BIRC3
Tchem
Novelty: 0.00189613
Score: 0.991
Data Source: Reactome,STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.989
Data Source: STRINGDB
TDP2
Tchem
Family: Enzyme
Novelty: 0.01104303
Score: 0.988
Data Source: STRINGDB
MAP3K1
Tchem
Family: Kinase
Novelty: 0.0041131
Score: 0.987
Data Source: STRINGDB
BIRC2
Tchem
Novelty: 0.00199701
Score: 0.985
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  3416.58

PubMed score by year
PubTator Score  2539.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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