COL5A3
Collagen alpha-3(V) chain
Protein Summary
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information ...more
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.71 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 105 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.71 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 105 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (81)
Nearest Tclin Targets
Pathways (303)
Reactome (5)
KEGG (1)
PathwayCommons (1)
WikiPathways (296)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Reactome | Collagen chain trimerization | ||||
Reactome | Collagen formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Collagen biosynthesis and modifying enzymes | ||||
Collagen chain trimerization | ||||
Collagen formation | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (5)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
blood protein measurement | 1 | 2 | 2 | 79.8 | |||||
age at menarche | 1 | 1 | 1 | 73.4 | |||||
triglyceride measurement | 16 | 2 | 16 | 63 | |||||
sleep duration | 1 | 1 | 1 | 60.2 | |||||
appendicular lean mass | 1 | 1 | 1 | 56.3 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
blood protein measurement | 2 | 79.8 | |||||
age at menarche | 1 | 73.4 | |||||
triglyceride measurement | 16 | 63 | |||||
sleep duration | 1 | 60.2 | |||||
appendicular lean mass | 1 | 56.3 | |||||
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IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | collagen type V alpha 3 chain | VGNC:14741 | 455692 | |||||
Mouse | MGI:1858212 | 53867 | ||||||
Rat | RGD:70922 | 60379 | ||||||
Dog | collagen type V alpha 3 chain | VGNC:39479 | 484961 | |||||
Horse | collagen type V alpha 3 chain [Source:HGNC Symbol;Acc:HGNC:14864] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | collagen type V alpha 3 chain | |||||
Mouse | ||||||
Rat | ||||||
Dog | collagen type V alpha 3 chain | |||||
Horse | collagen type V alpha 3 chain [Source:HGNC Symbol;Acc:HGNC:14864] | |||||
Publication Statistics
PubMed Score 14.71
PubMed score by year
PubTator Score 13.98
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (3)
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0 of 0
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