You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
COL5A3
Collagen alpha-3(V) chain

Protein Summary
Description
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264828
  • ENSP00000264828
  • ENSG00000080573
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.63
PubMedID
0.61
transcription factor perturbation
0.61
phenotype
0.6
disease
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.1   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.1   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
ADAMTS14
Tbio
Family:  Enzyme
Novelty:  0.07885034
Score:  0.96
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.95
Data Source:  STRINGDB
ADAMTS2
Tbio
Family:  Enzyme
Novelty:  0.00852208
Score:  0.944
Data Source:  STRINGDB
COL5A1
Tbio
Novelty:  0.00506815
Score:  0.943
Data Source:  STRINGDB
COL16A1
Tbio
Novelty:  0.11147945
Score:  0.942
Data Source:  STRINGDB
ADAMTS3
Tbio
Family:  Enzyme
Novelty:  0.00578975
Score:  0.94
Data Source:  STRINGDB
COL6A2
Tbio
Novelty:  0.01275082
Score:  0.935
Data Source:  STRINGDB
COL4A2
Tbio
Novelty:  0.00782053
Score:  0.933
Data Source:  STRINGDB
COL6A1
Tbio
Novelty:  0.00644855
Score:  0.931
Data Source:  STRINGDB
COL4A1
Tbio
Novelty:  0.00358049
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (303)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
1
1
58.4
1
1
0
1.3
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
58.4
0
1.3
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type V alpha 3 chain
VGNC:14741
455692
Mouse
MGI:1858212
53867
Rat
RGD:70922
60379
Dog
collagen type V alpha 3 chain
VGNC:39479
484961
Horse
collagen type V alpha 3 chain [Source:HGNC Symbol;Acc:HGNC:14864]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type V alpha 3 chain
Mouse
Rat
Dog
collagen type V alpha 3 chain
Horse
collagen type V alpha 3 chain [Source:HGNC Symbol;Acc:HGNC:14864]
Publication Statistics
PubMed Score 14.10
PubMed score by year
PubTator Score 13.98
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title