Protein Summary
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]
- ENST00000335790
- ENSP00000338207
- ENSG00000166407
- ENST00000428101
- ENSP00000404538
- RBTN1
- RHOM1
- TTG1
- TTG1
- RBTN1
- RHOM1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.8 | ||
PubMedID | 0.72 | ||
transcription factor binding site profile | 0.71 | ||
trait | 0.61 | ||
transcription factor | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.32 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 145 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.32 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 145 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (103)
LDB1
Novelty: 0.01110112
p_int: 0.999999987
p_ni: 1.3e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
TRIO
Family: Kinase
Novelty: 0.03113573
p_int: 0.999999979
p_ni: 2e-8
p_wrong: 1e-9
Data Source: BioPlex
SSBP3
Novelty: 0.01955714
p_int: 0.999999965
p_ni: 3.5e-8
Score: 0.512
Data Source: BioPlex,STRINGDB
SSBP4
Novelty: 0.27365687
p_int: 0.999999789
p_ni: 1.82e-7
p_wrong: 2.9e-8
Score: 0.262
Data Source: BioPlex,STRINGDB
SSBP2
Novelty: 0.06546999
p_int: 0.999999443
p_ni: 5.54e-7
p_wrong: 4e-9
Score: 0.528
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | RUNX1 regulates transcription of genes involved in differentiation of HSCs | ||||
Reactome | Transcriptional regulation by RUNX1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
RUNX1 regulates transcription of genes involved in differentiation of HSCs | ||||
Transcriptional regulation by RUNX1 | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (1)
Components (2)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 2 | 0 | 1.3 | 78.2 | |||||
parental genotype effect measurement | 1 | 1 | 1 | 73.7 | |||||
birth weight | 1 | 1 | 1 | 73.7 | |||||
body height | 1 | 1 | 1 | 21.5 | |||||
glucose measurement | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 78.2 | |||||
parental genotype effect measurement | 1 | 73.7 | |||||
birth weight | 1 | 73.7 | |||||
body height | 1 | 21.5 | |||||
glucose measurement | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | LIM domain only 1 | VGNC:3249 | 749084 | |||||
Macaque | LIM domain only 1 | 100425589 | ||||||
Mouse | MGI:102812 | 109594 | ||||||
Dog | LIM domain only 1 | VGNC:42722 | 610473 | |||||
Horse | LIM domain only 1 | VGNC:19709 | 100055468 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | LIM domain only 1 | |||||
Macaque | LIM domain only 1 | |||||
Mouse | ||||||
Dog | LIM domain only 1 | |||||
Horse | LIM domain only 1 | |||||
Publication Statistics
PubMed Score 63.32
PubMed score by year
PubTator Score 40.39
PubTator score by year
Related Publications
Text Mined References (45)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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