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Tbio
LMO1
Rhombotin-1

Protein Summary
Description
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335790
  • ENSP00000338207
  • ENSG00000166407
  • ENST00000428101
  • ENSP00000404538

Symbol
  • RBTN1
  • RHOM1
  • TTG1
  • TTG1
  • RBTN1
  • RHOM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.8
PubMedID
0.72
transcription factor binding site profile
0.71
trait
0.61
transcription factor
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.32   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.32   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.3
78.2
parental genotype effect measurement
1
1
1
73.7
birth weight
1
1
1
73.7
body height
1
1
1
21.5
glucose measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
78.2
parental genotype effect measurement
1
73.7
birth weight
1
73.7
body height
1
21.5
glucose measurement
1
17.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM domain only 1
VGNC:3249
749084
Macaque
LIM domain only 1
100425589
Mouse
MGI:102812
109594
Dog
LIM domain only 1
VGNC:42722
610473
Horse
LIM domain only 1
VGNC:19709
100055468
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM domain only 1
Macaque
LIM domain only 1
Mouse
Dog
LIM domain only 1
Horse
LIM domain only 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P25800-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Reactome
Transcriptional regulation by RUNX1
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Transcriptional regulation by RUNX1
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (103)
1 – 10 of 103
LMO3
Tbio
Novelty:  0.03437083
p_int:  0.999999997
p_wrong:  3e-9
Data Source:  BioPlex
ZBTB43
Tdark
Family:  TF
Novelty:  0.35735342
p_int:  0.999999996
p_ni:  3e-9
Data Source:  BioPlex
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999999993
p_ni:  6e-9
Data Source:  BioPlex
LDB1
Tbio
Novelty:  0.01110112
p_int:  0.999999987
p_ni:  1.3e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
MN1
Tbio
Novelty:  0.0015395
p_int:  0.999999985
p_ni:  1.5e-8
Data Source:  BioPlex
TRIO
Tbio
Family:  Kinase
Novelty:  0.03113573
p_int:  0.999999979
p_ni:  2e-8
p_wrong:  1e-9
Data Source:  BioPlex
UBE3D
Tbio
Family:  Enzyme
Novelty:  0.44919491
p_int:  0.999999972
p_ni:  2.8e-8
Data Source:  BioPlex
SSBP3
Tbio
Novelty:  0.01955714
p_int:  0.999999965
p_ni:  3.5e-8
Score:  0.512
Data Source:  BioPlex,STRINGDB
SSBP4
Tdark
Novelty:  0.27365687
p_int:  0.999999789
p_ni:  1.82e-7
p_wrong:  2.9e-8
Score:  0.262
Data Source:  BioPlex,STRINGDB
SSBP2
Tbio
Novelty:  0.06546999
p_int:  0.999999443
p_ni:  5.54e-7
p_wrong:  4e-9
Score:  0.528
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  63.32

PubMed score by year
PubTator Score  40.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer