Protein Summary
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
- ENST00000257818
- ENSP00000257818
- ENSG00000135363
- ENST00000395833
- ENSP00000379175
- ENST00000411482
- ENSP00000401967
- RBTN2
- RBTNL1
- RHOM2
- TTG2
- TTG2
- LMO-2
- RBTN2
- RHOM2
- RBTNL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.99 | ||
virus perturbation | 0.99 | ||
molecular function | 0.98 | ||
kinase perturbation | 0.96 | ||
disease perturbation | 0.93 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 276.28 (req: < 5)
Gene RIFs: 75 (req: <= 3)
Antibodies: 682 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 276.28 (req: >= 5)
Gene RIFs: 75 (req: > 3)
Antibodies: 682 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 83.4 | |||||
red blood cell density measurement | 1 | 1 | 1 | 82 | |||||
monocyte count | 1 | 1 | 1 | 52.9 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 52.6 | |||||
mean corpuscular volume | 1 | 1 | 1 | 51.8 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 83.4 | |||||
red blood cell density measurement | 1 | 82 | |||||
monocyte count | 1 | 52.9 | |||||
mean reticulocyte volume | 1 | 52.6 | |||||
mean corpuscular volume | 1 | 51.8 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | LIM domain only 2 | VGNC:3248 | 738727 | |||||
Macaque | LIM domain only 2 | 717502 | ||||||
Mouse | MGI:102811 | 16909 | ||||||
Rat | RGD:1307101 | 362176 | ||||||
Dog | LIM domain only 2 [Source:HGNC Symbol;Acc:HGNC:6642] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | LIM domain only 2 | |||||
Macaque | LIM domain only 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | LIM domain only 2 [Source:HGNC Symbol;Acc:HGNC:6642] | |||||
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (7)
Reactome (5)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | RUNX1 regulates transcription of genes involved in differentiation of HSCs | ||||
Reactome | Transcriptional regulation by RUNX1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
RUNX1 regulates transcription of genes involved in differentiation of HSCs | ||||
Transcriptional regulation by RUNX1 | ||||
Gene Ontology Terms (15)
Functions (8)
Components (2)
Processes (5)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (182)
1 – 10 of 182
GORAB
Novelty: 0.06288992
p_int: 0.999999986
p_wrong: 1.4e-8
Score: 0.182
Data Source: BioPlex,STRINGDB
RECQL5
Family: Enzyme
Novelty: 0.01558497
p_int: 0.999999948
p_ni: 5.1e-8
p_wrong: 1e-9
Score: 0.618
Data Source: BioPlex,STRINGDB
MEX3D
Novelty: 0.02245732
p_int: 0.999999878
p_ni: 1.21e-7
p_wrong: 1e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
LDB1
Novelty: 0.01110112
p_int: 0.999999701
p_ni: 2.95e-7
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MN1
Novelty: 0.0015395
p_int: 0.999999518
p_ni: 5.1e-8
p_wrong: 4.31e-7
Score: 0.44
Data Source: BioPlex,STRINGDB
RNF31
Family: Enzyme
Novelty: 0.01394304
p_int: 0.999998951
p_ni: 0.000001049
Data Source: BioPlex
RBCK1
Novelty: 0.02760333
p_int: 0.999997922
p_ni: 0.000002078
Data Source: BioPlex
RPAP2
Family: Enzyme
Novelty: 0.03383659
p_int: 0.999994677
p_ni: 0.000005323
Score: 0.519
Data Source: BioPlex,STRINGDB
SSBP3
Novelty: 0.01955714
p_int: 0.999993645
p_ni: 0.000006355
Score: 0.742
Data Source: BioPlex,STRINGDB
SSBP2
Novelty: 0.06546999
p_int: 0.999993429
p_ni: 0.00000657
p_wrong: 2e-9
Score: 0.77
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 276.28
PubMed score by year
PubTator Score 174.66
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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