Protein Summary
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]
- ENST00000257818
- ENSP00000257818
- ENSG00000135363
- ENST00000395833
- ENSP00000379175
- ENST00000411482
- ENSP00000401967
- RBTN2
- RBTNL1
- RHOM2
- TTG2
- TTG2
- LMO-2
- RBTN2
- RHOM2
- RBTNL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.99 | ||
virus perturbation | 0.99 | ||
molecular function | 0.98 | ||
kinase perturbation | 0.96 | ||
disease perturbation | 0.93 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 212 (req: < 5)
Gene RIFs: 75 (req: <= 3)
Antibodies: 682 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 212 (req: >= 5)
Gene RIFs: 75 (req: > 3)
Antibodies: 682 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (7)
Reactome (5)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | RUNX1 regulates transcription of genes involved in differentiation of HSCs | ||||
Reactome | Transcriptional regulation by RUNX1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
RUNX1 regulates transcription of genes involved in differentiation of HSCs | ||||
Transcriptional regulation by RUNX1 | ||||
Gene Ontology Terms (15)
Functions (8)
Components (2)
Processes (5)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (182)
1 – 10 of 182
GORAB
Novelty: 0.05020497
p_int: 0.999999986
p_wrong: 1.4e-8
Score: 0.182
Data Source: BioPlex,STRINGDB
RECQL5
Family: Enzyme
Novelty: 0.01938916
p_int: 0.999999948
p_ni: 5.1e-8
p_wrong: 1e-9
Score: 0.618
Data Source: BioPlex,STRINGDB
MEX3D
Novelty: 0.02473644
p_int: 0.999999878
p_ni: 1.21e-7
p_wrong: 1e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
LDB1
Novelty: 0.00548345
p_int: 0.999999701
p_ni: 2.95e-7
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MN1
Novelty: 0.00146056
p_int: 0.999999518
p_ni: 5.1e-8
p_wrong: 4.31e-7
Score: 0.44
Data Source: BioPlex,STRINGDB
RNF31
Family: Enzyme
Novelty: 0.01498949
p_int: 0.999998951
p_ni: 0.000001049
Data Source: BioPlex
RBCK1
Novelty: 0.02344672
p_int: 0.999997922
p_ni: 0.000002078
Data Source: BioPlex
RPAP2
Family: Enzyme
Novelty: 0.07575758
p_int: 0.999994677
p_ni: 0.000005323
Score: 0.519
Data Source: BioPlex,STRINGDB
SSBP3
Novelty: 0.02698795
p_int: 0.999993645
p_ni: 0.000006355
Score: 0.742
Data Source: BioPlex,STRINGDB
SSBP2
Novelty: 0.07797045
p_int: 0.999993429
p_ni: 0.00000657
p_wrong: 2e-9
Score: 0.77
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 212.00
PubMed score by year
PubTator Score 174.66
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRR
1-70
LYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINS
70-140
DIVCEQDIYEWTKINGMI
140-158
MSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKINGMI
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