Protein Summary
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
- ENST00000368985
- ENSP00000357981
- ENSG00000163131
- ENST00000448301
- ENSP00000408414
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.99 | ||
transcription factor perturbation | 0.94 | ||
kinase perturbation | 0.93 | ||
disease perturbation | 0.9 | ||
gene perturbation | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 250.4 (req: < 5)
Gene RIFs: 134 (req: <= 3)
Antibodies: 408 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 250.4 (req: >= 5)
Gene RIFs: 134 (req: > 3)
Antibodies: 408 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1806
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3