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Tbio
MT3
Metallothionein-3

Protein Summary
Description
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro. This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000200691
  • ENSP00000200691
  • ENSG00000087250

Symbol
  • GIF
  • GIFB
  • GRIF
  • ZnMT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.88
protein domain
0.73
chemical
0.66
histone modification site profile
0.57


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 306.07   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 306.07   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P25713-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Metallothioneins bind metals
Reactome
Response to metal ions
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Metallothioneins bind metals
Response to metal ions
Gene Ontology Terms (79)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (126)
1 – 10 of 126
MTF1
Tbio
Family: TF
Novelty: 0.01350821
Score: 0.755
Data Source: STRINGDB
SLC30A1
Tbio
Family: Transporter
Novelty: 0.00528427
Score: 0.709
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.708
Data Source: STRINGDB
SLC30A3
Tbio
Family: Transporter
Novelty: 0.00683607
Score: 0.697
Data Source: STRINGDB
HPGDS
Tchem
Family: Enzyme
Novelty: 0.00019629
Score: 0.633
Data Source: STRINGDB
GFAP
Tbio
Novelty: 0.00020932
Score: 0.623
Data Source: STRINGDB
ATOX1
Tbio
Novelty: 0.00509938
Score: 0.613
Data Source: STRINGDB
SOD1
Tbio
Family: Enzyme
Novelty: 0.00039653
Score: 0.611
Data Source: STRINGDB
SLC39A12
Tbio
Family: Transporter
Novelty: 0.09127395
Score: 0.608
Data Source: STRINGDB
SNCB
Tbio
Novelty: 0.00743454
Score: 0.596
Data Source: STRINGDB
Publication Statistics
PubMed Score  306.07

PubMed score by year
PubTator Score  312.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer