Tbio ATP5F1A ATP synthase subunit alpha, mitochondrial

Protein Summary

Description

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (PubMed:30146159). This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• P25705
• A8K092
• B4DY56
• K7ENP3
• Q53XX6
• Q8IXV2
• Q96FB4
• Q96HW2
• Q96IR6
• Q9BTV8

Gene Name

• ATP5F1A

Ensembl ID

• ENST00000282050
• ENSP00000282050
• ENSG00000152234
• ENST00000398752
• ENSP00000381736
• ENST00000590665
• ENSP00000467037
• ENST00000593152
• ENSP00000465477

Symbol

• ATP5A
• ATP5A1
• ATP5AL2
• ATPM
• OMR
• ORM
• ATPM
• MOM2
• ATP5A
• hATP1
• ATP5A1
• MC5DN4
• ATP5AL2
• COXPD22
• HEL-S-123m

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Atp Synthase Subunit Alpha, Mitochondrial

Protein / Transporter / Ion Channel / Anion Channel / Atp Synthase Subunit Alpha, Mitochondrial

Protein / Transporter / Cation Transporter / Atp Synthase / Atp Synthase Subunit Alpha, Mitochondrial

Protein / Receptor / Ligand-gated Ion Channel / Atp Synthase Subunit Alpha, Mitochondrial

Protein / Nucleic Acid Binding / Dna Binding Protein / Atp Synthase Subunit Alpha, Mitochondrial

Protein / Hydrolase / Atp Synthase Subunit Alpha, Mitochondrial

DTO Classes

Protein / Transporter / F-type And V-type Atpases / F-type Atpase / Atp Synthase Subunit Alpha, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.65   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 291   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.65   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0