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Tbio
DNAJB2
DnaJ homolog subfamily B member 2

Protein Summary
Description
Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336576
  • ENSP00000338019
  • ENSG00000135924
  • ENST00000392086
  • ENSP00000375936

Symbol
  • HSJ1
  • HSPF3
  • HSJ1
  • CMT2T
  • DSMA5
  • HSJ-1
  • HSPF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
histone modification site profile
0.79
disease perturbation
0.74
small molecule perturbation
0.72
transcription factor
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.8   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.8   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
3
8
95.7
reticulocyte measurement
3
2
5
92.7
mean reticulocyte volume
1
2
2
77.5
red blood cell distribution width
2
1
2
75.3
body mass index
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
8
95.7
reticulocyte measurement
5
92.7
mean reticulocyte volume
2
77.5
red blood cell distribution width
2
75.3
body mass index
1
61.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B2
VGNC:50727
743367
Macaque
DnaJ heat shock protein family (Hsp40) member B2
702936
Mouse
MGI:1928739
56812
Rat
RGD:1591035
689593
Dog
DnaJ heat shock protein family (Hsp40) member B2
100683427
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B2
Macaque
DnaJ heat shock protein family (Hsp40) member B2
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member B2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P25686-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (35)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (74)
1 – 10 of 74
DNAJB8
Tbio
Novelty:  0.0791748
p_int:  0.999999477
p_ni:  5.23e-7
Score:  0.215
Data Source:  BioPlex,STRINGDB
CYHR1
Tdark
Novelty:  0.04771996
p_int:  0.999980154
p_ni:  0.000019846
Score:  0.2
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999725198
p_ni:  0.000274802
Score:  0.312
Data Source:  BioPlex,STRINGDB
LACC1
Tbio
Family:  Enzyme
Novelty:  0.03928871
p_int:  0.999227168
p_ni:  0.000765463
p_wrong:  0.000007369
Score:  0.154
Data Source:  BioPlex,STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.999219963
p_ni:  0.000780037
Data Source:  BioPlex
TRO
Tbio
Novelty:  0.02850833
p_int:  0.998582645
p_ni:  0.001403863
p_wrong:  0.000013492
Data Source:  BioPlex
RFWD3
Tbio
Family:  Enzyme
Novelty:  0.0859205
p_int:  0.997995444
p_ni:  0.002004551
p_wrong:  5e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
NSMCE4A
Tdark
Novelty:  0.45550673
p_int:  0.992873702
p_ni:  0.007126298
Data Source:  BioPlex
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
p_int:  0.9115792
p_ni:  0.0884208
Score:  0.202
Data Source:  BioPlex,STRINGDB
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
p_int:  0.909244509
p_ni:  0.090755491
Score:  0.214
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  20.80

PubMed score by year
PubTator Score  19.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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