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Tbio
FAS
Tumor necrosis factor receptor superfamily member 6

Protein Summary
Description
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355279
  • ENSP00000347426
  • ENSG00000026103
  • ENST00000355740
  • ENSP00000347979
  • ENST00000357339
  • ENSP00000349896
  • ENST00000479522
  • ENSP00000424113
  • ENST00000484444
  • ENSP00000420975
  • ENST00000488877
  • ENSP00000425159
  • ENST00000492756
  • ENSP00000422453
  • ENST00000494410
  • ENSP00000423755

Symbol
  • APT1
  • FAS1
  • TNFRSF6
  • APT1
  • CD95
  • FAS1
  • APO-1
  • FASTM
  • ALPS1A
  • TNFRSF6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
biological process
0.98
virus perturbation
0.94
gene perturbation
0.93
hub protein
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2177   (req: < 5)
Gene RIFs: 891   (req: <= 3)
Antibodies: 2611   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2177   (req: >= 5)
Gene RIFs: 891   (req: > 3)
Antibodies: 2611   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.3
84.5
tumor necrosis factor receptor superfamily member 6 measurement
1
2
2
82.1
blood protein measurement
1
1
1
80.9
testosterone measurement
1
1
1
54.4
systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, rheumatoid factor negative, oligoarticular juvenile idiopathic arthritis
1
1
0
1.2
30.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
84.5
tumor necrosis factor receptor superfamily member 6 measurement
2
82.1
blood protein measurement
1
80.9
testosterone measurement
1
54.4
systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, rheumatoid factor negative, oligoarticular juvenile idiopathic arthritis
0
1.2
30.9
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (74)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
CASP8 activity is inhibited
Reactome
Caspase activation via Death Receptors in the presence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Apoptosis
CASP8 activity is inhibited
Caspase activation via Death Receptors in the presence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Death Receptor Signalling
Gene Ontology Terms (35)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (264)
1 – 10 of 264
CASP8
Tchem
Family: Enzyme
Novelty: 0.00024321
p_int: 0.999999548
p_ni: 4.5e-7
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
FADD
Tbio
Novelty: 0.00137968
p_int: 0.999992736
p_ni: 0.000007217
p_wrong: 4.7e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
FAM118B
Tdark
Novelty: 0.48168976
p_int: 0.999986481
p_ni: 0.000013519
Data Source: BioPlex
RHOBTB3
Tbio
Novelty: 0.09149494
p_int: 0.997702597
p_ni: 0.002297274
p_wrong: 1.28e-7
Data Source: BioPlex
FAM91A1
Tbio
Novelty: 0.76982657
p_int: 0.99730304
p_ni: 0.002696729
p_wrong: 2.31e-7
Score: 0.516
Data Source: BioPlex,STRINGDB
GPD1L
Tbio
Family: Enzyme
Novelty: 0.0169606
p_int: 0.996436452
p_ni: 0.003563548
Data Source: BioPlex
C17orf75
Tbio
Novelty: 0.08706784
p_int: 0.983957396
p_ni: 0.016042603
p_wrong: 1e-9
Score: 0.71
Data Source: BioPlex,STRINGDB
UGDH
Tbio
Family: Enzyme
Novelty: 0.00284931
p_int: 0.981620059
p_ni: 0.018379941
Score: 0.183
Data Source: BioPlex,STRINGDB
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.981483043
p_ni: 0.018516957
Score: 0.164
Data Source: BioPlex,STRINGDB
MAP1S
Tbio
Novelty: 0.02643414
p_int: 0.967084051
p_ni: 0.032915948
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  2177.00

PubMed score by year
PubTator Score  1887.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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