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Tchem
BRD2
Bromodomain-containing protein 2

Protein Summary
Description
May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374825
  • ENSP00000363958
  • ENSG00000204256
  • ENST00000374831
  • ENSP00000363964
  • ENST00000383108
  • ENSP00000372588
  • ENSG00000234507
  • ENST00000395287
  • ENSP00000378702
  • ENST00000399527
  • ENSP00000382443
  • ENSG00000215077
  • ENST00000399528
  • ENSP00000382444
  • ENST00000399529
  • ENSP00000382445
  • ENST00000414731
  • ENSP00000391246
  • ENSG00000234704
  • ENST00000436979
  • ENSP00000405634
  • ENSG00000235307
  • ENST00000438194
  • ENSP00000401791
  • ENST00000442863
  • ENSP00000410994
  • ENST00000448067
  • ENSP00000412885
  • ENST00000449085
  • ENSP00000409145
  • ENST00000449118
  • ENSP00000399009
  • ENST00000549126
  • ENSP00000449380
  • ENST00000552587
  • ENSP00000449609

Symbol
  • KIAA9001
  • RING3
  • FSH
  • NAT
  • RNF3
  • FSRG1
  • RING3
  • D6S113E
  • O27.1.1
  • BRD2-IT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
drug perturbation
0.87
kinase perturbation
0.84
transcription factor
0.84
phenotype
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.15   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.15   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 209
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (209)
1 – 10 of 209
CHEMBL3220922
chemical structure image
CHEMBL98350
chemical structure image
CHEMBL2177300
chemical structure image
CHEMBL3963603
chemical structure image
CHEMBL1957266
chemical structure image
CHEMBL3955162,CHEMBL3941065
chemical structure image
CHEMBL3910920
chemical structure image
CHEMBL3929288
chemical structure image
CHEMBL3910409
chemical structure image
CHEMBL3895277
chemical structure image
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.4
51.6
1
1
0
2.4
51.6
1
1
0
2.4
51.6
1
1
0
2.4
51.6
1
1
0
2.4
51.6
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.4
51.6
0
2.4
51.6
0
2.4
51.6
0
2.4
51.6
0
2.4
51.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
bromodomain containing 2
717893
Mouse
MGI:99495
14312
Rat
RGD:11509343
108348112
Dog
bromodomain containing 2
VGNC:38519
474868
Horse
bromodomain containing 2
VGNC:15882
100052542
Species
Name
OMA
EggNOG
Inparanoid
Macaque
bromodomain containing 2
Mouse
Rat
Dog
bromodomain containing 2
Horse
bromodomain containing 2
Protein Data Bank (60)
1 – 5 of 60
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX3 regulates p14-ARF
Reactome
Transcriptional regulation by RUNX3
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX3 regulates p14-ARF
Transcriptional regulation by RUNX3
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (171)
1 – 10 of 171
FAM90A1
Tdark
Novelty: 0.95155075
p_int: 0.999999985
p_ni: 1.5e-8
Score: 0.787
Data Source: BioPlex,STRINGDB
BRD3
Tchem
Family: Epigenetic
Novelty: 0.00335409
p_int: 0.99999957
p_ni: 4.25e-7
p_wrong: 5e-9
Score: 0.922
Data Source: BioPlex,STRINGDB
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.999998627
p_ni: 0.000001373
Score: 0.265
Data Source: BioPlex,STRINGDB
CAMKV
Tbio
Family: Kinase
Novelty: 0.17794181
p_int: 0.99999827
p_ni: 0.000001729
Score: 0.331
Data Source: BioPlex,STRINGDB
PES1
Tbio
Novelty: 0.07162845
p_int: 0.999996208
p_ni: 0.000003792
Score: 0.429
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.997437203
p_ni: 0.002562783
p_wrong: 1.4e-8
Score: 0.689
Data Source: BioPlex,STRINGDB
EPB41L5
Tbio
Novelty: 0.0391959
p_int: 0.99566932
p_ni: 0.00433068
Score: 0.728
Data Source: BioPlex,STRINGDB
MDK
Tchem
Novelty: 0.00145301
p_int: 0.971571217
p_ni: 0.028147842
p_wrong: 0.00028094
Score: 0.33
Data Source: BioPlex,STRINGDB
DENND2D
Tbio
Novelty: 0.16496649
p_int: 0.969261446
p_ni: 0.030738525
p_wrong: 2.9e-8
Score: 0.55
Data Source: BioPlex,STRINGDB
NOG
Tbio
Novelty: 0.0010373
p_int: 0.962468068
p_ni: 0.037530137
p_wrong: 0.000001795
Data Source: BioPlex
Publication Statistics
PubMed Score  192.15

PubMed score by year
PubTator Score  479.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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