BRD2
Bromodomain-containing protein 2
Protein Summary
May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided ...more
- ENST00000374825
- ENSP00000363958
- ENSG00000204256
- ENST00000374831
- ENSP00000363964
- ENST00000383108
- ENSP00000372588
- ENSG00000234507
- ENST00000395287
- ENSP00000378702
- ENST00000399527
- ENSP00000382443
- ENSG00000215077
- ENST00000399528
- ENSP00000382444
- ENST00000399529
- ENSP00000382445
- ENST00000414731
- ENSP00000391246
- ENSG00000234704
- ENST00000436979
- ENSP00000405634
- ENSG00000235307
- ENST00000438194
- ENSP00000401791
- ENST00000442863
- ENSP00000410994
- ENST00000448067
- ENSP00000412885
- ENST00000449085
- ENSP00000409145
- ENST00000449118
- ENSP00000399009
- ENST00000549126
- ENSP00000449380
- ENST00000552587
- ENSP00000449609
- KIAA9001
- RING3
- FSH
- NAT
- RNF3
- FSRG1
- RING3
- D6S113E
- O27.1.1
- BRD2-IT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.87 | ||
drug perturbation | 0.87 | ||
kinase perturbation | 0.84 | ||
transcription factor | 0.84 | ||
phenotype | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 252.46 (req: < 5)
Gene RIFs: 58 (req: <= 3)
Antibodies: 335 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 252.46 (req: >= 5)
Gene RIFs: 58 (req: > 3)
Antibodies: 335 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 292
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0