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Tbio
RPS12
40S ribosomal protein S12

Protein Summary
Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230050
  • ENSP00000230050
  • ENSG00000112306

Symbol
  • S12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
small molecule perturbation
1
interacting protein
0.99
microRNA
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.06   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.06   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (468)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.839790691
p_ni:  0.160209308
p_wrong:  1e-9
Score:  0.557
Data Source:  BioPlex,STRINGDB
RPS23
Tbio
Novelty:  0.01846154
Score:  0.999
Data Source:  STRINGDB
RPS16
Tbio
Novelty:  0.00261983
Score:  0.999
Data Source:  STRINGDB
RPL36
Tbio
Novelty:  0.02259932
Score:  0.999
Data Source:  STRINGDB
RPL7A
Tbio
Novelty:  0.01674027
Score:  0.999
Data Source:  STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
Score:  0.999
Data Source:  STRINGDB
RPS5
Tbio
Novelty:  0.00513677
Score:  0.999
Data Source:  STRINGDB
RPL34
Tbio
Novelty:  0.02236592
Score:  0.999
Data Source:  STRINGDB
RPL10
Tbio
Novelty:  0.01299391
Score:  0.999
Data Source:  STRINGDB
RPS14
Tbio
Novelty:  0.00576737
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (18)
1 – 5 of 18
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S12
VGNC:3689
747115
Macaque
40S ribosomal protein S12
706087
Mouse
MGI:98105
20042
Mouse
MGI:3704503
100034727
Rat
RGD:62024
65139
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S12
Macaque
40S ribosomal protein S12
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 197.06
PubMed score by year
PubTator Score 51.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title