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Tbio
LAMA1
Laminin subunit alpha-1

Protein Summary
Description
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389658
  • ENSP00000374309
  • ENSG00000101680

Symbol
  • LAMA
  • LAMA
  • PTBHS
  • S-LAM-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.97
gene perturbation
0.96
transcription factor perturbation
0.8
PubMedID
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.08   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.08   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
3
1.1
66.2
risk-taking behaviour
1
1
1
29
sudden cardiac arrest
1
1
0
1.4
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
66.2
risk-taking behaviour
1
29
sudden cardiac arrest
0
1.4
3.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99892
16772
Rat
RGD:1307207
316758
Dog
laminin subunit alpha 1
VGNC:42564
102156629
Cow
laminin subunit alpha 1
VGNC:30769
506387
Opossum
laminin subunit alpha 1
100015923
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
laminin subunit alpha 1
Cow
laminin subunit alpha 1
Opossum
laminin subunit alpha 1
Protein Structure (0 Structures, 10 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (42)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
ECM proteoglycans
Extracellular matrix organization
L1CAM interactions
Gene Ontology Terms (26)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (139)
1 – 10 of 139
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999998928
p_ni:  0.000001062
p_wrong:  1e-8
Score:  0.6
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.999995247
p_ni:  0.000004752
Score:  0.53
Data Source:  BioPlex,STRINGDB
CRP
Tbio
Novelty:  0.00001517
p_int:  0.99584339
p_ni:  0.004043419
p_wrong:  0.000113191
Score:  0.179
Data Source:  BioPlex,STRINGDB
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.86145029
p_ni:  0.033351806
p_wrong:  0.105197904
Score:  0.18
Data Source:  BioPlex,STRINGDB
OS9
Tbio
Novelty:  0.01490339
p_int:  0.811524898
p_ni:  0.002767113
p_wrong:  0.185707989
Data Source:  BioPlex
DAG1
Tbio
Family:  Enzyme
Novelty:  0.00149278
Score:  0.987
Data Source:  Reactome,STRINGDB
NID1
Tbio
Novelty:  0.00169075
Score:  0.972
Data Source:  STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.962
Data Source:  STRINGDB
ITGA1
Tbio
Novelty:  0.00545805
Score:  0.958
Data Source:  STRINGDB
ITGA6
Tbio
Novelty:  0.00217985
Score:  0.957
Data Source:  STRINGDB
Publication Statistics
PubMed Score  118.08

PubMed score by year
PubTator Score  91.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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