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Tchem
MPST
3-mercaptopyruvate sulfurtransferase

Protein Summary
Description
Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions. This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochond ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341116
  • ENSP00000342333
  • ENSG00000128309
  • ENST00000397225
  • ENSP00000380402
  • ENST00000401419
  • ENSP00000384812
  • ENST00000404802
  • ENSP00000383950
  • ENST00000429360
  • ENSP00000411719

Symbol
  • TST2
  • MST
  • TST2
  • TUM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
disease perturbation
0.74
gene perturbation
0.68
tissue sample
0.66
tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.76   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.76   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
I3MT-3
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
85.6
red blood cell distribution width
1
1
1
85.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
85.6
red blood cell distribution width
1
85.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mercaptopyruvate sulfurtransferase
695842
Mouse
MGI:2179733
246221
Rat
RGD:620065
192172
Dog
mercaptopyruvate sulfurtransferase
VGNC:43351
474515
Horse
mercaptopyruvate sulfurtransferase
VGNC:20298
100069619
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mercaptopyruvate sulfurtransferase
Mouse
Rat
Dog
mercaptopyruvate sulfurtransferase
Horse
mercaptopyruvate sulfurtransferase
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Degradation of cysteine and homocysteine (R-HSA-1614558)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of cysteine and homocysteine
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Degradation of cysteine and homocysteine
Metabolism
Metabolism of amino acids and derivatives
Sulfur amino acid metabolism
Protein-Protein Interactions (65)
1 – 10 of 65
CTH
Tchem
Family: Enzyme
Novelty: 0.0017155
Score: 0.994
Data Source: STRINGDB
SUOX
Tbio
Family: Enzyme
Novelty: 0.00971136
Score: 0.988
Data Source: STRINGDB
NFS1
Tbio
Family: Enzyme
Novelty: 0.01274706
Score: 0.973
Data Source: STRINGDB
MOCS3
Tbio
Family: Enzyme
Novelty: 0.039209
Score: 0.961
Data Source: STRINGDB
ETHE1
Tbio
Family: Enzyme
Novelty: 0.01397214
Score: 0.96
Data Source: STRINGDB
CYCS
Tchem
Novelty: 0.00014004
Score: 0.956
Data Source: STRINGDB
GOT1
Tbio
Family: Enzyme
Novelty: 0.00448817
Score: 0.939
Data Source: STRINGDB
CBSL
Tdark
Novelty: 0.00062189
Score: 0.928
Data Source: STRINGDB
CBS
Tchem
Family: Enzyme
Novelty: 0.00063091
Score: 0.928
Data Source: STRINGDB
GOT2
Tbio
Family: Enzyme
Novelty: 0.00054023
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  153.76

PubMed score by year
PubTator Score  96.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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