Tbio MPST 3-mercaptopyruvate sulfurtransferase

Protein Summary

Description

Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions. This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P25325
• A8MZ34
• B3KP52
• J3KPV7
• O75750
• Q6FHN9
• MST

Gene Name

• MPST

Ensembl ID

• ENST00000341116
• ENSP00000342333
• ENSG00000128309
• ENST00000397225
• ENSP00000380402
• ENST00000401419
• ENSP00000384812
• ENST00000404802
• ENSP00000383950
• ENST00000429360
• ENSP00000411719

Symbol

• TST2
• MST
• TST2
• TUM1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.81
disease perturbation	0.74
gene perturbation	0.68
tissue sample	0.66
tissue	0.62

Protein Classes

PANTHER Classes

Protein / Transferase / 3-mercaptopyruvate Sulfurtransferase

Protein / Transfer/carrier Protein / 3-mercaptopyruvate Sulfurtransferase

DTO Classes

Protein / Enzyme / Transferase / 3-mercaptopyruvate Sulfurtransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.28   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.28   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0