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Tbio
AZGP1
Zinc-alpha-2-glycoprotein

Protein Summary
Description
Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292401
  • ENSP00000292401
  • ENSG00000160862

Symbol
  • ZAG
  • ZNGP1
  • ZAG
  • ZA2G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
interacting protein
0.76
molecular function
0.73
kinase perturbation
0.71
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.98   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.98   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999360081
p_ni:  0.000639919
Data Source:  BioPlex
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.989555112
p_ni:  0.010444888
Data Source:  BioPlex
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.984789614
p_ni:  0.015210386
Data Source:  BioPlex
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.949006709
p_ni:  0.050993291
Data Source:  BioPlex
EFEMP1
Tbio
Novelty:  0.00574779
p_int:  0.822076859
p_ni:  0.177923141
Data Source:  BioPlex
GK
Tbio
Family:  Kinase
Novelty:  0.00617547
p_int:  0.778779339
p_ni:  0.221220661
Score:  0.183
Data Source:  BioPlex,STRINGDB
C16orf70
Tdark
Novelty:  2.12573065
p_int:  0.76181298
p_ni:  0.23818702
Score:  0.183
Data Source:  BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.754655488
p_ni:  0.245344512
Data Source:  BioPlex
PIP
Tbio
Novelty:  0.00208509
Score:  0.991
Data Source:  Reactome,STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.664
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Miscellaneous transport and binding events (R-HSA-5223345)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Miscellaneous transport and binding events
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Miscellaneous transport and binding events
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
82.4
testosterone measurement
1
1
1
81.6
serum metabolite measurement
1
1
2
73.9
body height
1
1
1
62.1
1
1
0
1.3
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
82.4
testosterone measurement
1
81.6
serum metabolite measurement
2
73.9
body height
1
62.1
0
1.3
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha-2-glycoprotein 1, zinc-binding
VGNC:14071
737709
Macaque
alpha-2-glycoprotein 1, zinc-binding
710136
Mouse
MGI:103163
12007
Rat
RGD:2187
25294
Dog
alpha-2-glycoprotein 1, zinc-binding
VGNC:38327
479739
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha-2-glycoprotein 1, zinc-binding
Macaque
alpha-2-glycoprotein 1, zinc-binding
Mouse
Rat
Dog
alpha-2-glycoprotein 1, zinc-binding
Publication Statistics
PubMed Score 280.98
PubMed score by year
PubTator Score 221.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title