Tbio MCM3 DNA replication licensing factor MCM3

Protein Summary

Description

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]

Uniprot Accession IDs

• P25205
• B4DWW4
• Q92660
• Q9BTR3
• Q9NUE7

Gene Name

• MCM3

Ensembl ID

• ENST00000229854
• ENSP00000229854
• ENSG00000112118
• ENST00000596288
• ENSP00000472940
• ENST00000616552
• ENSP00000480987

Symbol

• HCC5
• P1.h
• RLFB
• P1-MCM3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
co-expressed gene	0.99
kinase perturbation	0.96
disease perturbation	0.95
molecular function	0.95

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Dna Replication Licensing Factor Mcm3

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Dna Replication Licensing Factor Mcm3

Protein / Hydrolase / Dna Replication Licensing Factor Mcm3

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Dna Replication Licensing Factor Mcm3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.56   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 461   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.56   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 461   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0