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Tbio
MPZ
Myelin protein P0

Protein Summary
Description
Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough m ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000463290
  • ENSP00000431538
  • ENSG00000158887
  • ENST00000533357
  • ENSP00000432943

Symbol
  • P0
  • CHM
  • DSS
  • MPP
  • CHN2
  • CMT1
  • CMT1B
  • CMT2I
  • CMT2J
  • CMT4E
  • CMTDI3
  • CMTDID
  • HMSNIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.74
phenotype
0.69
cell type or tissue
0.62
biological term
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.74   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.74   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myelin protein zero
VGNC:1328
747431
Macaque
myelin protein zero
719969
Mouse
MGI:103177
17528
Rat
RGD:3109
24564
Dog
myelin protein zero
VGNC:43353
488654
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myelin protein zero
Macaque
myelin protein zero
Mouse
Rat
Dog
myelin protein zero
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P25189-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
ProtInc
Protein-Protein Interactions (65)
1 – 10 of 65
PMP22
Tbio
Novelty: 0.00256307
Score: 0.919
Data Source: STRINGDB
GJB1
Tbio
Novelty: 0.00109019
Score: 0.86
Data Source: STRINGDB
MPZL1
Tbio
Novelty: 0.03292508
Score: 0.817
Data Source: STRINGDB
SOX10
Tbio
Family: TF
Novelty: 0.00130552
Score: 0.807
Data Source: STRINGDB
EGR2
Tbio
Family: TF
Novelty: 0.00215433
Score: 0.793
Data Source: STRINGDB
GDAP1
Tbio
Novelty: 0.00682376
Score: 0.767
Data Source: STRINGDB
PRX
Tbio
Novelty: 0.01867283
Score: 0.758
Data Source: STRINGDB
MBP
Tbio
Novelty: 0.00016333
Score: 0.753
Data Source: STRINGDB
PLP1
Tbio
Novelty: 0.00129083
Score: 0.727
Data Source: STRINGDB
SH3TC2
Tbio
Novelty: 0.0205934
Score: 0.721
Data Source: STRINGDB
Publication Statistics
PubMed Score  448.74

PubMed score by year
PubTator Score  432.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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