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Tclin
TACR1
Substance-P receptor

Protein Summary
Description
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305249
  • ENSP00000303522
  • ENSG00000115353
  • ENST00000409848
  • ENSP00000386448

Symbol
  • NK1R
  • TAC1R
  • SPR
  • NK1R
  • NKIR
  • TAC1R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
ligand (chemical)
0.97
biological term
0.91
disease
0.77
chemical
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1743.74   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 530   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1743.74   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 530   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1847
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6