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Tclin
TACR1
Substance-P receptor

Protein Summary
Description
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305249
  • ENSP00000303522
  • ENSG00000115353
  • ENST00000409848
  • ENSP00000386448

Symbol
  • NK1R
  • TAC1R
  • SPR
  • NK1R
  • NKIR
  • TAC1R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
ligand (chemical)
0.97
biological term
0.91
disease
0.77
chemical
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1643.48   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 530   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1643.48   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 530   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1829
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.7
1.3
response to diisocyanate
1
1
0
2.7
1.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.7
1.3
response to diisocyanate
0
2.7
1.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tachykinin receptor 1
VGNC:393
470412
Macaque
tachykinin receptor 1
653008
Mouse
MGI:98475
21336
Rat
RGD:3811
24807
Dog
tachykinin receptor 1
VGNC:47066
403815
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tachykinin receptor 1
Macaque
tachykinin receptor 1
Mouse
Rat
Dog
tachykinin receptor 1
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (39)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Clathrin-mediated endocytosis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Class A/1 (Rhodopsin-like receptors)
Clathrin-mediated endocytosis
G alpha (q) signalling events
GPCR downstream signalling
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (368)
1 – 10 of 368
RDH14
Tdark
Family: Enzyme
Novelty: 0.35816611
p_int: 0.999712521
p_ni: 0.000239164
p_wrong: 0.000048315
Data Source: BioPlex
CAV1
Tbio
Novelty: 0.00035244
p_int: 0.99960269
p_ni: 0.00039731
p_wrong: 1e-9
Score: 0.174
Data Source: BioPlex,STRINGDB
FADS1
Tchem
Family: Enzyme
Novelty: 0.00160193
p_int: 0.999142144
p_ni: 0.000856814
p_wrong: 0.000001041
Score: 0.208
Data Source: BioPlex,STRINGDB
SLMAP
Tbio
Novelty: 0.03974856
p_int: 0.996896865
p_ni: 0.003103135
Data Source: BioPlex
NDUFB8
Tclin
Family: Enzyme
Novelty: 0.019021
p_int: 0.996047562
p_ni: 0.003952435
p_wrong: 2e-9
Score: 0.252
Data Source: BioPlex,STRINGDB
PKP2
Tbio
Novelty: 0.00493803
p_int: 0.992332758
p_ni: 0.007667242
Data Source: BioPlex
ARVCF
Tbio
Novelty: 0.03248592
p_int: 0.992216637
p_ni: 0.007783349
p_wrong: 1.5e-8
Data Source: BioPlex
MT-CO1
Tchem
Family: Enzyme
Novelty: 0.00008262
p_int: 0.989197509
p_ni: 0.010802346
p_wrong: 1.44e-7
Data Source: BioPlex
GPR89A
Tbio
Family: IC
Novelty: 0.06782776
p_int: 0.987203043
p_ni: 0.012796953
p_wrong: 4e-9
Data Source: BioPlex
ARL6IP5
Tbio
Novelty: 0.00871985
p_int: 0.986145271
p_ni: 0.013854729
Data Source: BioPlex
Publication Statistics
PubMed Score  1643.48

PubMed score by year
PubTator Score  970.05

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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