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Tclin
EDNRA
Endothelin-1 receptor

Protein Summary
Description
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324300
  • ENSP00000315011
  • ENSG00000151617
  • ENST00000358556
  • ENSP00000351359
  • ENST00000506066
  • ENSP00000425281
  • ENST00000510697
  • ENSP00000427259
  • ENST00000511804
  • ENSP00000425354
  • ENST00000648866
  • ENSP00000496976

Symbol
  • ETA
  • ETRA
  • ETA
  • ET-A
  • ETAR
  • ETRA
  • MFDA
  • ETA-R
  • hET-AR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.92
transcription factor perturbation
0.84
chemical
0.82
disease
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1942.75   (req: < 5)
Gene RIFs: 147   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1942.75   (req: >= 5)
Gene RIFs: 147   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 698
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
66.4
platelet crit
2
2
2
64.8
red blood cell density measurement
1
1
1
62.4
hemoglobin measurement
1
1
1
60.4
hematocrit
1
1
1
50.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
66.4
platelet crit
2
64.8
red blood cell density measurement
1
62.4
hemoglobin measurement
1
60.4
hematocrit
1
50.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endothelin receptor type A
VGNC:594
461530
Macaque
endothelin receptor type A
704135
Mouse
MGI:105923
13617
Rat
RGD:2535
24326
Dog
endothelin receptor type A
VGNC:40202
450187
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endothelin receptor type A
Macaque
endothelin receptor type A
Mouse
Rat
Dog
endothelin receptor type A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P25101-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (244)
1 – 10 of 244
BCL2L11
Tbio
Novelty: 0.00055914
p_int: 0.994878599
p_ni: 0.005121396
p_wrong: 5e-9
Score: 0.553
Data Source: BioPlex,STRINGDB
MCL1
Tchem
Novelty: 0.00046181
p_int: 0.980366422
p_ni: 0.019633577
p_wrong: 1e-9
Score: 0.561
Data Source: BioPlex,STRINGDB
MTX1
Tbio
Novelty: 0.02350764
p_int: 0.97084787
p_ni: 0.02915213
Score: 0.181
Data Source: BioPlex,STRINGDB
ARL5B
Tbio
Family: Enzyme
Novelty: 0.03703395
p_int: 0.941469891
p_ni: 0.058510427
p_wrong: 0.000019682
Score: 0.19
Data Source: BioPlex,STRINGDB
LMBR1
Tbio
Novelty: 0.00591824
p_int: 0.902245521
p_ni: 0.096104913
p_wrong: 0.001649566
Score: 0.187
Data Source: BioPlex,STRINGDB
MT-ND1
Tclin
Family: Enzyme
Novelty: 0.00090183
p_int: 0.875744027
p_ni: 0.097652729
p_wrong: 0.026603245
Score: 0.175
Data Source: BioPlex,STRINGDB
EBP
Tchem
Family: Enzyme
Novelty: 0.00610658
p_int: 0.861392487
p_ni: 0.137217551
p_wrong: 0.001389961
Score: 0.211
Data Source: BioPlex,STRINGDB
SYNGR2
Tbio
Novelty: 0.1089664
p_int: 0.860654258
p_ni: 0.13932102
p_wrong: 0.000024722
Score: 0.211
Data Source: BioPlex,STRINGDB
MT-CO1
Tchem
Family: Enzyme
Novelty: 0.00008262
p_int: 0.798530801
p_ni: 0.201451169
p_wrong: 0.00001803
Score: 0.181
Data Source: BioPlex,STRINGDB
EDN1
Tbio
Novelty: 0.00007453
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1942.75

PubMed score by year
PubTator Score  2210.99

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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