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Tchem
GRK2
Beta-adrenergic receptor kinase 1

Protein Summary
Description
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308595
  • ENSP00000312262
  • ENSG00000173020

Symbol
  • ADRBK1
  • BARK
  • BARK1
  • BARK1
  • ADRBK1
  • BETA-ARK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 593.66   (req: < 5)
Gene RIFs: 139   (req: <= 3)
Antibodies: 626   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 593.66   (req: >= 5)
Gene RIFs: 139   (req: > 3)
Antibodies: 626   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 73
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (659)
GRK3
Tchem
Family:  Kinase
Novelty:  0.01912864
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.967
Data Source:  BioPlex,STRINGDB
PPP1R16B
Tbio
Family:  Enzyme
Novelty:  0.08773047
p_int:  0.999991127
p_ni:  0.000008867
p_wrong:  6e-9
Score:  0.361
Data Source:  BioPlex,STRINGDB
TBC1D14
Tbio
Novelty:  0.25089884
p_int:  0.999595419
p_ni:  0.000404581
Score:  0.239
Data Source:  BioPlex,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
Score:  0.995
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.994
Data Source:  STRINGDB
SMO
Tclin
Family:  GPCR
Novelty:  0.03235855
Score:  0.99
Data Source:  Reactome,STRINGDB
ARRB1
Tbio
Novelty:  0.00262758
Score:  0.987
Data Source:  STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
Score:  0.982
Data Source:  STRINGDB
ADRB2
Tclin
Family:  GPCR
Novelty:  0.00041821
Score:  0.981
Data Source:  Reactome,STRINGDB
AGTR1
Tclin
Family:  GPCR
Novelty:  0.00033439
Score:  0.98
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
CCR5
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CXCR4
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CCR4
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
OPRM1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
Pathways (48)
Activation of SMO (R-HSA-5635838)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
Ca-dependent events
Reactome
CaM pathway
Reactome
Calmodulin induced events
Reactome
Cargo recognition for clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Activation of SMO
Ca-dependent events
CaM pathway
Calmodulin induced events
Cargo recognition for clathrin-mediated endocytosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
3
2
4
84
mean corpuscular volume
1
1
1
74.2
BMI-adjusted hip circumference
1
1
1
72.9
appendicular lean mass
1
1
1
72.9
lipid measurement
1
1
1
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
4
84
mean corpuscular volume
1
74.2
BMI-adjusted hip circumference
1
72.9
appendicular lean mass
1
72.9
lipid measurement
1
68.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor kinase 2
VGNC:10432
451363
Macaque
G protein-coupled receptor kinase 2
721754
Mouse
MGI:87940
110355
Rat
RGD:2062
25238
Cow
G protein-coupled receptor kinase 2
282682
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor kinase 2
Macaque
G protein-coupled receptor kinase 2
Mouse
Rat
Cow
G protein-coupled receptor kinase 2
Publication Statistics
PubMed Score 593.66
PubMed score by year
PubTator Score 470.20
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title