GRK2
Beta-adrenergic receptor kinase 1
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Most Knowledge About | Knowledge Value
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biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
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cellular component | 0 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of SMO | ||||
Reactome | Ca-dependent events | ||||
Reactome | CaM pathway | ||||
Reactome | Calmodulin induced events | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of SMO | ||||
Ca-dependent events | ||||
CaM pathway | ||||
Calmodulin induced events | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 2 | 2 | 3 | 92.7 | |||||
mean corpuscular volume | 1 | 1 | 1 | 83.8 | |||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 82.5 | |||||
waist circumference | 1 | 1 | 1 | 71.5 | |||||
red blood cell distribution width | 1 | 1 | 1 | 60.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 3 | 92.7 | |||||
mean corpuscular volume | 1 | 83.8 | |||||
BMI-adjusted hip circumference | 1 | 82.5 | |||||
waist circumference | 1 | 71.5 | |||||
red blood cell distribution width | 1 | 60.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor kinase 2 | VGNC:10432 | 451363 | |||||
Macaque | G protein-coupled receptor kinase 2 | 721754 | ||||||
Mouse | MGI:87940 | 110355 | ||||||
Rat | RGD:2062 | 25238 | ||||||
Cow | G protein-coupled receptor kinase 2 | 282682 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor kinase 2 | |||||
Macaque | G protein-coupled receptor kinase 2 | |||||
Mouse | ||||||
Rat | ||||||
Cow | G protein-coupled receptor kinase 2 | |||||
PMID | Year | Title |
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