GRK2
Beta-adrenergic receptor kinase 1
Protein Classes
Protein Summary
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity). This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism ...more
- ENST00000308595
- ENSP00000312262
- ENSG00000173020
- ADRBK1
- BARK
- BARK1
- BARK1
- ADRBK1
- BETA-ARK1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 565.26 (req: < 5)
Gene RIFs: 139 (req: <= 3)
Antibodies: 626 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 565.26 (req: >= 5)
Gene RIFs: 139 (req: > 3)
Antibodies: 626 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 67
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (67)
1 – 10 of 67
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 2 | 2 | 3 | 92.7 | |||||
mean corpuscular volume | 1 | 1 | 1 | 83.8 | |||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 82.5 | |||||
waist circumference | 1 | 1 | 1 | 71.5 | |||||
red blood cell distribution width | 1 | 1 | 1 | 60.5 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 3 | 92.7 | |||||
mean corpuscular volume | 1 | 83.8 | |||||
BMI-adjusted hip circumference | 1 | 82.5 | |||||
waist circumference | 1 | 71.5 | |||||
red blood cell distribution width | 1 | 60.5 | |||||
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor kinase 2 | VGNC:10432 | 451363 | |||||
Macaque | G protein-coupled receptor kinase 2 | 721754 | ||||||
Mouse | MGI:87940 | 110355 | ||||||
Rat | RGD:2062 | 25238 | ||||||
Cow | G protein-coupled receptor kinase 2 | 282682 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor kinase 2 | |||||
Macaque | G protein-coupled receptor kinase 2 | |||||
Mouse | ||||||
Rat | ||||||
Cow | G protein-coupled receptor kinase 2 | |||||
Protein Structure (16 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 16
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (48)
Reactome (21)
KEGG (6)
PathwayCommons (18)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 21
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of SMO | ||||
Reactome | Ca-dependent events | ||||
Reactome | CaM pathway | ||||
Reactome | Calmodulin induced events | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of SMO | ||||
Ca-dependent events | ||||
CaM pathway | ||||
Calmodulin induced events | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
Gene Ontology Terms (25)
Functions (6)
Components (5)
Processes (14)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (659)
1 – 10 of 659
GRK3
Family: Kinase
Novelty: 0.01912864
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.967
Data Source: BioPlex,STRINGDB
PPP1R16B
Family: Enzyme
Novelty: 0.08773047
p_int: 0.999991127
p_ni: 0.000008867
p_wrong: 6e-9
Score: 0.361
Data Source: BioPlex,STRINGDB
TBC1D14
Novelty: 0.25089884
p_int: 0.999595419
p_ni: 0.000404581
Score: 0.239
Data Source: BioPlex,STRINGDB
GNG2
Novelty: 0.04807242
Score: 0.995
Data Source: STRINGDB
GNB1
Novelty: 0.02477955
Score: 0.994
Data Source: STRINGDB
SMO
Family: GPCR
Novelty: 0.03235855
Score: 0.99
Data Source: Reactome,STRINGDB
ARRB1
Novelty: 0.00262758
Score: 0.987
Data Source: STRINGDB
ARRB2
Novelty: 0.00148149
Score: 0.982
Data Source: STRINGDB
ADRB2
Family: GPCR
Novelty: 0.00041821
Score: 0.981
Data Source: Reactome,STRINGDB
AGTR1
Family: GPCR
Novelty: 0.00033439
Score: 0.98
Data Source: STRINGDB
Publication Statistics
PubMed Score 565.26
PubMed score by year
PubTator Score 470.2
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
Find similar targets by:
UniProt Keyword
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GWAS Trait
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