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Tclin
GUCY2C
Heat-stable enterotoxin receptor

Protein Summary
Description
Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin. This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive). [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261170
  • ENSP00000261170
  • ENSG00000070019

Symbol
  • GUC2C
  • STAR
  • GC-C
  • STAR
  • DIAR6
  • GUC2C
  • MECIL
  • MUCIL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.97
co-expressed gene
0.76
gene perturbation
0.68
disease
0.6


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.63   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.63   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
linaclotide
Rendered image for linaclotide
plecanatide
Rendered image for plecanatide
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
21.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 2C
VGNC:5410
473375
Mouse
MGI:106903
14917
Rat
RGD:2771
25711
Dog
guanylate cyclase 2C
VGNC:41569
486671
Horse
guanylate cyclase 2C
VGNC:18662
100063810
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase 2C
Mouse
Rat
Dog
guanylate cyclase 2C
Horse
guanylate cyclase 2C
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P25092-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Reactome
Disease
Reactome
Infectious disease
Reactome
Intestinal infectious diseases
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Disease
Infectious disease
Intestinal infectious diseases
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (170)
1 – 10 of 170
ATP5IF1
Tbio
Family:  Enzyme
Novelty:  0.01272196
p_int:  0.991584233
p_ni:  8e-9
p_wrong:  0.008415759
Data Source:  BioPlex
GUCA2A
Tbio
Novelty:  0.00856211
Score:  0.994
Data Source:  Reactome,STRINGDB
GUCA2B
Tbio
Family:  Enzyme
Novelty:  0.02002363
Score:  0.977
Data Source:  Reactome,STRINGDB
NUDT2
Tbio
Family:  Enzyme
Novelty:  0.0201004
Score:  0.9
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.9
Data Source:  STRINGDB
PDE5A
Tclin
Family:  Enzyme
Novelty:  0.00032205
Score:  0.895
Data Source:  STRINGDB
PDZD3
Tbio
Novelty:  0.08821289
Score:  0.87
Data Source:  STRINGDB
GGCT
Tchem
Family:  Enzyme
Novelty:  0.01154389
Score:  0.866
Data Source:  STRINGDB
GLYAT
Tbio
Family:  Enzyme
Novelty:  0.02347543
Score:  0.866
Data Source:  STRINGDB
DOCK11
Tdark
Novelty:  0.0295159
Score:  0.856
Data Source:  STRINGDB
Publication Statistics
PubMed Score  501.63

PubMed score by year
PubTator Score  345.82

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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