You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
FPR3
N-formyl peptide receptor 3

Protein Summary
Description
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339223
  • ENSP00000341821
  • ENSG00000187474
  • ENST00000595991
  • ENSP00000470471

Symbol
  • FPRH1
  • FPRL2
  • FMLPY
  • FPRH1
  • FPRH2
  • FPRL2
  • RMLP-R-I
  • FMLP-R-II
  • FML2_HUMAN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.97
hub protein
0.79
tissue sample
0.68
protein domain
0.58
gene perturbation
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.34   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.34   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0