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Tchem
FPR3
N-formyl peptide receptor 3

Protein Summary
Description
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339223
  • ENSP00000341821
  • ENSG00000187474
  • ENST00000595991
  • ENSP00000470471

Symbol
  • FPRH1
  • FPRL2
  • FMLPY
  • FPRH1
  • FPRH2
  • FPRL2
  • RMLP-R-I
  • FMLP-R-II
  • FML2_HUMAN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.97
hub protein
0.79
tissue sample
0.68
protein domain
0.58
gene perturbation
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.89   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.89   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
LXA<sub>4</sub>
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
3
5
85.4
eosinophil percentage of leukocytes
1
1
1
40.3
eosinophil count
1
1
1
39.6
electrocardiography
1
1
1
14.5
neutrophil percentage of leukocytes
1
1
1
13.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
85.4
eosinophil percentage of leukocytes
1
40.3
eosinophil count
1
39.6
electrocardiography
1
14.5
neutrophil percentage of leukocytes
1
13.8
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
formyl peptide receptor 3
719802
Species
Name
OMA
EggNOG
Inparanoid
Macaque
formyl peptide receptor 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P25089-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Formyl peptide receptors bind formyl peptides and many other ligands
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Formyl peptide receptors bind formyl peptides and many other ligands
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (249)
1 – 10 of 249
HEBP1
Tbio
Novelty: 0.05672188
Score: 0.99
Data Source: Reactome,STRINGDB
ANXA1
Tbio
Novelty: 0.00103537
Score: 0.975
Data Source: Reactome,STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
Score: 0.937
Data Source: STRINGDB
CCR5
Tclin
Family: GPCR
Novelty: 0.00022549
Score: 0.936
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.935
Data Source: STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.934
Data Source: STRINGDB
TMIGD3
Tchem
Novelty: 0.00089511
Score: 0.933
Data Source: STRINGDB
C3AR1
Tchem
Family: GPCR
Novelty: 0.00527301
Score: 0.933
Data Source: STRINGDB
ADORA3
Tchem
Family: GPCR
Novelty: 0.00089511
Score: 0.933
Data Source: STRINGDB
CCR1
Tchem
Family: GPCR
Novelty: 0.00218065
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  94.89

PubMed score by year
PubTator Score  34.84

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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