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Tbio
COL8A2
Collagen alpha-2(VIII) chain

Protein Summary
Description
Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). This gene encodes the alpha 2 chain of type VIII collagen. This protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303143
  • ENSP00000305913
  • ENSG00000171812
  • ENST00000397799
  • ENSP00000380901

Symbol
  • FECD
  • PPCD
  • FECD1
  • PPCD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
PubMedID
0.64
tissue sample
0.59
cell line
0.57
microRNA
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.3   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.3   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
3
3
4
78
corneal topography
1
1
1
60.5
central corneal thickness
2
1
0
2.1
52.6
appendicular lean mass
1
1
1
49.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
78
corneal topography
1
60.5
central corneal thickness
0
2.1
52.6
appendicular lean mass
1
49.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type VIII alpha 2 chain
VGNC:11751
747856
Macaque
collagen type VIII alpha 2 chain
713447
Mouse
MGI:88464
329941
Rat
RGD:1305182
313592
Dog
collagen type VIII alpha 2 chain
VGNC:39485
482478
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type VIII alpha 2 chain
Macaque
collagen type VIII alpha 2 chain
Mouse
Rat
Dog
collagen type VIII alpha 2 chain
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P25067-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Extracellular matrix organization
Protein-Protein Interactions (84)
1 – 10 of 84
COL5A1
Tbio
Novelty: 0.00506815
p_int: 0.999999863
p_ni: 1.32e-7
p_wrong: 5e-9
Score: 0.939
Data Source: BioPlex,STRINGDB
COL2A1
Tbio
Novelty: 0.0011102
p_int: 0.999996793
p_ni: 0.000003207
Score: 0.97
Data Source: BioPlex,STRINGDB
COL14A1
Tbio
Novelty: 0.01760399
p_int: 0.999824585
p_ni: 0.000175415
Score: 0.928
Data Source: BioPlex,STRINGDB
FN1
Tchem
Novelty: 0.00003647
p_int: 0.999513545
p_ni: 0.000486455
Score: 0.359
Data Source: BioPlex,STRINGDB
COL4A5
Tbio
Novelty: 0.00283701
p_int: 0.993729678
p_ni: 0.000008699
p_wrong: 0.006261622
Score: 0.985
Data Source: BioPlex,STRINGDB
COLEC12
Tbio
Novelty: 0.02882427
p_int: 0.928206916
p_ni: 0.071793084
Score: 0.219
Data Source: BioPlex,STRINGDB
P4HA2
Tbio
Family: Enzyme
Novelty: 0.02097718
p_int: 0.903649951
p_ni: 0.096350046
p_wrong: 4e-9
Score: 0.921
Data Source: BioPlex,STRINGDB
COL4A2
Tbio
Novelty: 0.00782053
p_int: 0.869823895
p_ni: 0.130176085
p_wrong: 2.1e-8
Score: 0.955
Data Source: BioPlex,STRINGDB
COL18A1
Tbio
Novelty: 0.00074602
p_int: 0.860673321
p_ni: 0.139326679
Score: 0.923
Data Source: BioPlex,STRINGDB
FKBP14
Tbio
Family: Enzyme
Novelty: 0.02742616
p_int: 0.831429045
p_ni: 0.155150088
p_wrong: 0.013420867
Data Source: BioPlex
Publication Statistics
PubMed Score  53.30

PubMed score by year
PubTator Score  141.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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