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Tbio
CD24
Signal transducer CD24

Protein Summary
Description
May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity). This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000606017
  • ENSP00000475625
  • ENSG00000272398
  • ENST00000610952
  • ENSP00000483838
  • ENST00000619133
  • ENSP00000483985
  • ENST00000622315
  • ENSP00000481841

Symbol
  • CD24A
  • CD24A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
transcription factor perturbation
0.98
biological term
0.97
small molecule perturbation
0.79
PubMedID
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1081.84   (req: < 5)
Gene RIFs: 225   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1081.84   (req: >= 5)
Gene RIFs: 225   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P25063-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
L1CAM interactions
Protein-Protein Interactions (185)
1 – 10 of 185
CD44
Tbio
Novelty: 0.00011321
Score: 0.934
Data Source: STRINGDB
L1CAM
Tbio
Novelty: 0.00307041
Score: 0.923
Data Source: Reactome,STRINGDB
PROM1
Tbio
Novelty: 0.00037987
Score: 0.86
Data Source: STRINGDB
ERBB2
Tclin
Family: Kinase
Novelty: 0.00003761
Score: 0.847
Data Source: STRINGDB
EPCAM
Tbio
Novelty: 0.00042422
Score: 0.834
Data Source: STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.812
Data Source: STRINGDB
SELP
Tclin
Novelty: 0.00019779
Score: 0.79
Data Source: STRINGDB
ALDH1A1
Tchem
Family: Enzyme
Novelty: 0.0012292
Score: 0.785
Data Source: STRINGDB
ITGA6
Tbio
Novelty: 0.00217985
Score: 0.738
Data Source: STRINGDB
PTPRC
Tchem
Family: Enzyme
Novelty: 0.00012027
Score: 0.733
Data Source: STRINGDB
Publication Statistics
PubMed Score  1081.84

PubMed score by year
PubTator Score  667.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer