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Tchem
CXCR2
C-X-C chemokine receptor type 2

Protein Summary
Description
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318507
  • ENSP00000319635
  • ENSG00000180871

Symbol
  • IL8RB
  • CD182
  • IL8R2
  • IL8RA
  • IL8RB
  • CMKAR2
  • CDw128b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
1
biological process
0.94
gene perturbation
0.9
phenotype
0.79
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1037.19   (req: < 5)
Gene RIFs: 286   (req: <= 3)
Antibodies: 909   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1037.19   (req: >= 5)
Gene RIFs: 286   (req: > 3)
Antibodies: 909   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 510
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0