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Tchem
CXCR2
C-X-C chemokine receptor type 2

Protein Summary
Description
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318507
  • ENSP00000319635
  • ENSG00000180871

Symbol
  • IL8RB
  • CD182
  • IL8R2
  • IL8RA
  • IL8RB
  • CMKAR2
  • CDw128b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
1
biological process
0.94
gene perturbation
0.9
phenotype
0.79
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 923.13   (req: < 5)
Gene RIFs: 229   (req: <= 3)
Antibodies: 909   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 923.13   (req: >= 5)
Gene RIFs: 229   (req: > 3)
Antibodies: 909   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 431
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
3
3
4
93.3
neutrophil count
3
4
7
93
basophil count
2
3
3
83.9
lymphocyte percentage of leukocytes
2
4
6
75.6
leukocyte count
2
3
5
74.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
4
93.3
neutrophil count
7
93
basophil count
3
83.9
lymphocyte percentage of leukocytes
6
75.6
leukocyte count
5
74.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
C-X-C motif chemokine receptor 2
700407
Mouse
MGI:105303
12765
Rat
RGD:2906
29385
Dog
C-X-C motif chemokine receptor 2
478905
Dog
chemokine (C-X-C motif) receptor 1
478906
Species
Name
OMA
EggNOG
Inparanoid
Macaque
C-X-C motif chemokine receptor 2
Mouse
Rat
Dog
C-X-C motif chemokine receptor 2
Dog
chemokine (C-X-C motif) receptor 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P25025-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (39)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (41)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (368)
1 – 10 of 368
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.997
Data Source: STRINGDB
CXCL1
Tbio
Novelty: 0.00059123
Score: 0.995
Data Source: STRINGDB
CXCL5
Tbio
Novelty: 0.00286795
Score: 0.993
Data Source: STRINGDB
PPBP
Tbio
Novelty: 0.00048307
Score: 0.988
Data Source: STRINGDB
CXCL2
Tbio
Novelty: 0.00201175
Score: 0.987
Data Source: STRINGDB
CXCL3
Tbio
Novelty: 0.01001656
Score: 0.986
Data Source: STRINGDB
CXCL6
Tbio
Novelty: 0.01019922
Score: 0.982
Data Source: STRINGDB
CXCR1
Tchem
Family: GPCR
Novelty: 0.00224501
Score: 0.978
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.972
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  923.13

PubMed score by year
PubTator Score  529.36

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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