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Tchem
CXCR1
C-X-C chemokine receptor type 1

Protein Summary
Description
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.87
ligand (protein)
0.85
protein domain
0.73
cell type or tissue
0.7
molecular function
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 400.36   (req: < 5)
Gene RIFs: 131   (req: <= 3)
Antibodies: 549   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 400.36   (req: >= 5)
Gene RIFs: 131   (req: > 3)
Antibodies: 549   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 95
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
4.5
leukocyte count
1
1
1
2.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
4.5
leukocyte count
1
2.8
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine receptor 1
VGNC:154
470645
Macaque
C-X-C motif chemokine receptor 1
692074
Mouse
MGI:105303
12765
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine receptor 1
Macaque
C-X-C motif chemokine receptor 1
Mouse
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P25024-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (39)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (322)
1 – 10 of 322
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.996
Data Source: Reactome,STRINGDB
CXCL6
Tbio
Novelty: 0.01019922
Score: 0.99
Data Source: Reactome,STRINGDB
CXCL5
Tbio
Novelty: 0.00286795
Score: 0.984
Data Source: STRINGDB
CXCL1
Tbio
Novelty: 0.00059123
Score: 0.983
Data Source: STRINGDB
PPBP
Tbio
Novelty: 0.00048307
Score: 0.98
Data Source: STRINGDB
CXCR2
Tchem
Family: GPCR
Novelty: 0.00108314
Score: 0.978
Data Source: STRINGDB
CXCL2
Tbio
Novelty: 0.00201175
Score: 0.977
Data Source: STRINGDB
CXCL3
Tbio
Novelty: 0.01001656
Score: 0.97
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.968
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  400.36

PubMed score by year
PubTator Score  303.51

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer